Methods of using btl-ii proteins
AssigneeImmunex Corporation
InventorsPeter R. BAUM, Sabine S. Escobar, Joanne L. Viney
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Abstract
The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen.
Claims20
An isolated antibody that binds specifically to a BTL-II protein for use in promoting a systemic or mucosal immune response against an antigen,
- wherein the amino acid sequence of the BTL-II protein consists of a sequence starting at a position from 1-35 of SEQ ID NO:4 and ending at a position from 452-462 of SEQ ID NO:4.
A method of promoting a systemic or mucosal immune response against an antigen comprising administering to a patient in need thereof a therapeutically effective dose of an antibody that binds specifically to a BTL-II protein, wherein the amino acid sequence of the BTL-II protein consists of a sequence starting at a position from 1-35 of SEQ ID NO:4 and ending at a position from 452-462 of SEQ ID NO:4.
An antibody that binds to an immunogenic fragment of a BTL-II protein, wherein
- the immunogenic fragment comprises a fragment of the amino acid sequence of SEQ ID NO:10, 14, 16, or 18,
- the immunogenic fragment is at least 10 amino acids long, and
- the immunogenic fragment spans position 142 of SEQ ID NO:10, 14, or 18 or position 141 of SEQ ID NO:16.
A method of promoting a systemic or mucosal immune response against an antigen comprising administering to a patient in need thereof a therapeutically effective dose of an antibody that binds specifically to a BTL-II protein, wherein the amino acid sequence of the BTL-II protein consists of a sequence from 30-358 of SEQ ID NO:10, 14, 16, or 18.
Dependencies are inferred from the claim text.