Progenitor cells and uses thereof
AssigneeWhitehead Institute
InventorsRobert A. WEINBERG, Sendurai A. MANI, Mai-Jing LIAO
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Abstract
Methods for preparing progenitor cells are described where epithelial cells are induced to undergo epithelial-mesenchymal transition as a result of exposure to an inducing agent or introduction of a gene therein that induces epithelial-mesenchymal transition. Progenitor cells resulting therefrom have use in cell-based therapies, among other utilities.
Claims78
A method for generating progenitor cells from epithelial cells comprising the steps of
- a. obtaining a population of epithelial cells, and
- b. inducing epithelial-mesenchymal transition in the population of epithelial cells,
- whereby progenitor cells are generated in the population.
Progenitor cells prepared by the process of
- a. obtaining a population of epithelial cells, and
- b. inducing epithelial-mesenchymal transition in the population of epithelial cells.
Modified epithelial cells comprising an inducible gene encoding a protein that induces epithelial-mesenchymal transition when the cells are exposed to an inducer.
Modified progenitor cells comprising a vector comprising a gene encoding a protein that induces epithelial-mesenchymal transition.
Modified progenitor cells comprising an inducible gene encoding a protein that induces epithelial-mesenchymal transition;
- in combination with an inducer.
A method for administering cell therapy to a mammalian subject comprising transplanting into the subject progenitor cells prepared by the method of
- a. obtaining a population of epithelial cells,
- b. inducing epithelial-mesenchymal transition in the population of epithelial cells,
- whereby progenitor cells are generated in the population, and
- c. transplanting the progenitor cells into the subject.
Use of progenitor cells prepared by the steps of
- a. obtaining a population of epithelial cells,
- b. inducing epithelial-mesenchymal transition in the population of epithelial cells,
- whereby progenitor cells are generated in the population,
- for the preparation of a medicament for administration to a human in need of therapy for a disease.
A method for identifying a progenitor cell in a cellular population by detecting the expression of FOXC2 therein.
Dependencies are inferred from the claim text.