Methods and Compositions for Promoting Organ Development
AssigneeKintan Pty Ltd.
InventorsSharon D. Ricardo, David A. Hume, Melissa H. Little, Christina V. Jones
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Abstract
Compositions and methods are provided for promoting organ development in warm blooded animals, and in particular in certain aspects a premature infant or fetus. Compositions and methods are also provided for the administration of at least one colony stimulating factor-1 protein (CSF-1), precursor, variant, analogue, derivative thereof, or combinations thereof, or otherwise, at least one nucleic acid molecule encoding colony stimulating factor-1 protein (CSF-1), precursor, variant, analogue, derivative thereof, or combinations thereof.
Claims21
1-17. (canceled)
A method of treating a prematurely-birthed warm blooded animal, comprising:
- administering to said prematurely-birthed warm blooded animal a therapeutically effective amount of a composition comprising:
- i) colony stimulating factor-1 protein (CSF-1);
- ii) a precursor of CSF-1;
- iii) a variant of CSF-1, comprising an isoform of CSF-1;
- iv) an analogue of CSF-1 having retained substantial similarity in biological function to CSF-1;
- and/or
- v) a derivative of CSF-1 having retained substantial similarity in biological function to CSF-1;
- wherein the precursor, variant, analogue, or derivative of CSF-1 comprise the C-terminal fragment of CSF-1, comprising the C-terminal 150 amino acids of the 536 amino acid CSF-1 protein.
A method of treating a warm blooded animal, comprising:
- administering to said warm blooded animal a composition, comprising:
- i) colony stimulating factor-1 protein (CSF-1);
- ii) a precursor of CSF-1;
- iii) a variant of CSF-1, comprising an isoform of CSF-1;
- iv) an analogue of CSF-1 having retained substantial similarity in biological function to CSF-1;
- and/or
- v) a derivative of CSF-1 having retained substantial similarity in biological function to CSF-1;
- wherein:
- a) the precursor, variant, analogue, or derivative of CSF-1 comprise the C-terminal fragment of CSF-1, comprising the C-terminal 150 amino acids of the 536 amino acid CSF-1 protein;
- and
- b) the treatment of the warm blooded animal provides at least one of the following:
- 1) reduces, or limits one or more complications arising from or related to low birth weight;
- and
- 2) develops, enhances, grows, matures, promotes, or combinations thereof, an underdeveloped organ.
A composition, comprising:
- A) an organ developing, enhancing, or promoting amount of:
- i) colony stimulating factor-1 protein (CSF-1);
- ii) a precursor of CSF-1;
- iii) a variant of CSF-1, comprising an isoform of CSF-1;
- iv) an analogue of CSF-1 having retained substantial similarity in biological function to CSF-1;
- or
- v) a derivative of CSF-1 having retained substantial similarity in biological function to CSF-1;
- and
- B) at least one of a pharmaceutically acceptable excipient, vehicle, or diluent;
- wherein:
- a) the precursor, variant, analogue, or derivative of CSF-1 comprises the C-terminal fragment of CSF-1, comprising the C-terminal 150 amino acids of the 536 amino acid CSF-1 protein;
- and
- b) the amount develops, enhances, or promotes an underdeveloped organ in a warm blooded animal.
Dependencies are inferred from the claim text.