Optical fluorescent imaging
AssigneeLI-COR, Inc.
InventorsJoy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Abstract
Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
Claims30
A compound of formula (V):
- wherein Cat+ is a cation;
- X and Y are each (CH3)2C;
- and
- R8 and R13 are each independently alkyl, (CH2)rR25 or (CH2)rR18;
- wherein at least one of R8 and R13 is (CH2)rR18 and wherein r is an integer from 1 to 50, and R25 is a member selected from the group consisting of hydroxyl, thioacetyl, and sulfonato and R18 is carboxyl;
- R11 and R12 are each independently H, sulfonato, or together with the atoms to which they are bonded form an aromatic ring;
- and
- R16 and R17 are each independently H, sulfonato, or together with the atoms to which they are bonded form an aromatic ring.
A compound of the formula:
- wherein Cat+ is a cation;
- X and Y are each (CH3)2C;
- and
- R11 and R16 are each independently a member selected from the group consisting of hydrogen, sulfonato, and fluoro.
A method for imaging a subject, wherein the subject is administered a compound of the following formula:
- wherein Cat+ is a cation;
- X and Y are each (CH3)2C;
- and
- R8 and R13 are each independently alkyl, (CH2)rR25 or (CH2)rR18;
- wherein at least one of R8 and R13 is (CH2)rR18 and wherein r is an integer from 1 to 50, and R25 is a member selected from the group consisting of hydroxyl, thioacetyl, and sulfonato and R18 is carboxyl;
- R11 and R12 are each independently H, sulfonato, or together with the atoms to which they are bonded form an aromatic ring;
- and
- R16 and R17 are each independently H, sulfonato, or together with the atoms to which they are bonded form an aromatic ring, wherein the image is of a tumor, tissue or organ of the subject.
Dependencies are inferred from the claim text.