Lipid-based nanoparticles
OwnerAnanth Annapragada, Jason L. Eriksen +3inventors
InventorsAnanth Annapragada, Jason L. Eriksen, Eric A. Tanifum, Indrani Dasgupta, Stephen C. Cook
Life of this patent
Estimating the term…
Abstract
Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.
Claims22
A liposomal composition, comprising:
- a membrane, comprising:
- a phospholipid;
- cholesterol;
- a phospholipid derivatized with a polymer;
- and
- a phospholipid-polymer-aromatic compound conjugate;
- and
- a nonradioactive contrast enhancing agent at least one of encapsulated by or bound to the membrane.
A method for imaging amyloid deposits in a patient, the method comprising:
- introducing into the patient a detectable quantity of a liposomal composition comprising:
- a membrane, comprising:
- a phospholipid;
- cholesterol;
- a phospholipid derivatized with a polymer;
- and
- a phospholipid-polymer-aromatic compound conjugate;
- and
- a nonradioactive contrast enhancing agent at least one of encapsulated by or bound to the membrane;
- allowing sufficient time for the liposomal composition to be associated with one or more amyloid deposits;
- and
- detecting the liposomal composition associated with the one or more amyloid deposits.
A liposomal composition for capturing images of amyloid deposits on a patient's brain, the liposomal composition comprising:
- a membrane, comprising:
- DPPC;
- cholesterol;
- DSPE-mPEG-2000;
- and
- wherein n is about 10 to about 100,
- and wherein the membrane encapsulates iodixanol.
Dependencies are inferred from the claim text.