Validation method for automated analyzers

A method for validating the accuracy of automated analyzers comprising the steps of:

• designating as a validation target an automated analyzer that sequentially carries out automated analyses by dispensing an automated analysis target liquid into a plurality of optical analysis cells by a first and second analysis target liquid filling units;
• sequentially filling a first dye solution into the plurality of optical analysis cells by dispensing from a first liquid holding unit by using the first analysis target liquid filling unit;
• dispensing a second dye solution from a second liquid holding unit by using a diluent dispensing pipette;
• and
• weighing the diluent dispensing pipetter with the second dye solution using a diluent weighing unit;
• pipetting the second dye solution into the optical analysis cells filled with the first dye solution;
• placing a third dye solution into the optical analysis cells containing the first and second dye solutions, dispensed from a third liquid holding unit, using the second analysis target liquid filling unit;
• measuring a target liquid in the optical analysis cells comprising the first, second and third dye solutions by an optical absorbance detection unit, based on a dye method, to determine an amount of the first dye solution as a target liquid volume measurement result;
• weighing the diluent dispensing pipetter after pipetting the second dye solution by a pipetter weighing unit;
• transferring the target liquid from the optical analysis cells to a reference value measurement unit by using a transfer pipetter and measuring, based on the dye method, to determine by a second optical absorbance detection unit the amount of the first dye solution as a reference liquid volume measurement result;
• and
• validating the dispensing accuracy of the analysis target liquid dispensing unit of the automated analyzer by computing any deviation between and among the reference liquid volume measurement result and the target liquid volume measurement result and the measurement results of the pipetter weighing unit and the diluent weighing unit determined based on the gravimetric method.

A method for validating the accuracy of automated analyzers comprising:

• performing a dye method validation procedure that uses at least a first dye solution and second dye solution in a target test liquid;
• measuring the weight of the second dye solution;
• performing a first optical analysis on the target test liquid;
• performing a second optical analysis on the target test liquid;
• and
• performing a computational analysis to determine any deviation between and among the first and second optical analyses and the weight measurement for the second dye solution.