Autofluorescent organ phantom and associated method of production
AssigneeCommissariat A L'energie Atomique Et Aux Energies Alternatives
InventorAnne-Sophie Montcuquet
Life of this patent
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Abstract
A calibration device for instrumentation for medical imaging, also called a “phantom,” including a matrix. The calibration device includes at least one additive for simulating the autofluorescence properties of an organ or of a living tissue in the spectral band covering the red and near infrared, said additive belonging to the porphyrin class, such as protoporphyrin IX.
Claims18
A calibration device for instrumentation for medical imaging also called a “phantom” comprising a matrix, the matrix comprising at least one additive for simulating autofluorescence properties of an organ or of a living tissue in a spectral band covering the red and near infrared, said additive belonging to the porphyrin class.
A method of production of a calibration device or “phantom” for instrumentation for medical imaging, said calibration device comprising at least one matrix made according to at least the following stages:
- heating a volume of liquid water or saline buffer to a temperature between 30 and 40 degrees C.;
- adding a viscosity additive to said volume of liquid;
- cooling the mixture of liquid and viscosity additive to room temperature;
- adding a diffuser to the mixture of liquid and viscosity additive;
- adding an absorber to the liquid-viscosity additive-diffuser mixture;
- adding an additive belonging to the porphyrin class in a proportion between 1 to 1000 millionths of the volume of the starting liquid in the liquid-viscosity additive-diffuser-absorber mixture;
- cooling the liquid-viscosity additive-diffuser-absorber-additive mixture to a temperature of about 4° C. until the mixture hardens;
- and
- removing the mixture from a mould.
Dependencies are inferred from the claim text.