Human Ebola Virus Species and Compositions and Methods Thereof
AssigneeThe Government of the US as Represented by the Secretary of the Dept. of health
InventorsJonathan S. Towner, Stuart T. Nichol, James A. Comer, Thomas G. Ksiazek, Pierre E. Rollin
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Abstract
Compositions and methods including and related to the Ebola Bundibugyo virus (EboBun) are provided. Compositions are provided that are operable as immunogens to elicit and immune response or protection from EboBun challenge in a subject such as a primate. Inventive methods are directed to detection and treatment of EboBun infection.
Claims30
An isolated hEbola virus comprising a nucleic acid molecule comprising a nucleotide sequence of:
- a) a nucleotide sequence set forth in SEQ ID NOS:
- 1 or 10;
- b) a nucleotide sequence hybridizing under stringent conditions to SEQ ID NOS:
- 1 or 10;
- or
- c) a nucleotide sequence of at least 70%-99% identity to the SEQ ID NOS:
- 1 or 10, with the proviso that said nucleotide sequence is not SEQ ID NO:
- 20.
An isolated hEbola virus having Centers for Disease Control Deposit Accession No. 200706291.
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NOS:
- 1 or 10 or a complement thereof, or a fragment thereof wherein said fragment comprises a nucleotide sequence of between 4 and 4900 contiguous nucleotides of the nucleotide sequence of SEQ ID NOS:
- 1 or 10, or a complement thereof;
- with the proviso that said nucleotide sequence is not comprised by the nucleotide sequence set forth in SEQ ID NO:
- 20;
- or between 5500 and 6600 contiguous nucleotides of the nucleotide sequence of SEQ ID NOS:
- 1 or 10, or a complement thereof.
An isolated RNA or DNA nucleic acid molecule which hybridizes under stringent conditions to a nucleic acid molecule having the nucleotide sequence of SEQ ID NOS:
- 1 or 10 or a complement thereof.
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Dependencies are inferred from the claim text.