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US 2012/0239139 A1Published application
Medical implants containing fk506 (tacrolimus) methods of making and methods of use thereof
AssigneesAstellas Pharma Inc., Abbott Laboratories Vascular Entreprises Ltd.
InventorsStephan Wnendt, Randolf Von Oepen, Bernd Kuttler, Gerhard Lang, Guenter Lorenz, Axel Grandt
Life of this patent
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Abstract
Implants and methods of making same are provided for treatment or prophylaxis of coronary or peripheral vascular constrictions or vascular occlusions, and particularly, stenoses or restenoses, that comprise FK506 in chemically covalently bound, non-covalently bound or physically immobilized form.
Claims22
-33. (canceled)
An intravascular implant comprising:
- FK506 chemically covalently bound or non-covalently bound or physically immobilized to a substrate, and, optionally, at least one other active agent,
- wherein the implant comprises the substrate which is coated with FK506 and the substrate has at least one closed or perforated layer or surface which consists of a metal or a metal alloy and is homogenous or formed from various strands.
An implant produced by a process in which:
- a) a substrate having at least one closed or perforated layer or surface which consists of a metal or a metal alloy and is homogeneous or formed from various strands, which substrate is coated with a ceramic coating is employed,
- or
- b) a substrate having at least one closed or perforated layer or surface which consists of a polymer and is homogenous or formed from various strands is employed,
- or
- c) a substrate which is coated with a coating which is polymerized to form a methacrylate polymer, polyurethane, PTFE, hydrogel or hydrogel/polyurethane blend is employed
- or
- d) a substrate having at least one closed or perforated layer or surface which consists of a metal or a metal alloy and is homogenous or formed from various strands, and into which recesses have been introduced by means of a laser, which are filled with FK506, and then the substrate is coated with a biodegradable coating which is polymerized on the surface is employed;
- and wherein
- e) the substrate according to a), b), c) or d) is brought into contact with an FK506 solution in aqueous or organic solvent by sprinkling, spraying or immersing, optionally under vacuum,
- f) optionally, removing all or a portion of the organic solvent contacted contacted with the FK506 in step (e),
- g) optionally, repeating step (f) 1 to 5 times;
- and
- h) optionally, rinsing the substrate with water or isotonic saline;
- and
- i) optionally, drying the rinsed substrate of step (h).
12 more elements
Dependencies are inferred from the claim text.