Two-piece injectable drug delivery device with heat-cured seal

A method for manufacturing an injectable drug delivery device comprising:

• providing a first sheath having a first and second end;
• placing latanoprost or latanoprost acid into an interior region of the first sheath to form a drug core at least partially surrounded by the first sheath;
• providing a second sheath having a first and second end;
• and
• inserting the first sheath into an interior region of the second sheath such that the second sheath at least partially surrounds the first sheath.

A drug delivery device comprising:

• an inner casing comprising a) an inner wall defining a central cavity having a first and second end;
• an outer casing comprising b) an outer wall disposed about an exterior surface of the inner wall and c) a first outer cap sealing the outer casing adjacent to the second end;
• and
• a drug core comprising latanoprost or latanoprost acid disposed in the central cavity,
• wherein the first outer cap is permeable to latanoprost or latanoprost acid disposed in the central cavity.

A method for manufacturing a drug delivery device comprising:

• providing an inner casing comprising a) an inner wall defining a central cavity having a first and second end;
• placing latanoprost or latanoprost acid into the central cavity of the inner casing to form a drug core at least partially surrounded by the inner casing;
• and
• inserting the inner casing into an outer casing comprising b) an outer wall disposed about an exterior surface of the inner wall and c) a first outer cap sealing the outer casing adjacent to the second end,
• wherein the first outer cap is permeable to latanoprost or latanoprost acid in the drug core.

A drug delivery device comprising:

• an inner casing comprising an inner tube having a first and second end;
• an outer casing slidably engaged with the inner casing, the outer casing comprising an outer tube disposed about the inner tube and a first outer cap sealing an end of the outer casing adjacent to the second end;
• and
• a drug core comprising latanoprost or latanoprost acid disposed in the inner tube,
• wherein the first outer cap is permeable to latanoprost or latanoprost acid disposed in the central cavity.

A method for manufacturing a drug delivery device comprising:

• providing an inner casing comprising an inner tube having a first and second end;
• placing at least on drug selected from latanoprost and latanoprost acid into the inner tube to form a drug core at least partially surrounded by the inner casing;
• and
• slidably engaging an outer casing with the inner casing, the outer casing comprising an outer tube disposed about the inner tube and a first outer cap sealing an end of the outer casing adjacent to the second end,
• wherein the first outer cap is permeable to latanoprost or latanoprost acid in the drug core.

A drug delivery device comprising:

• an inner casing comprising an inner tube having a first and second end;
• an outer casing slidably engaged with the inner casing, the outer casing comprising an outer tube disposed about the inner tube and a first outer cap sealing an end of the outer casing adjacent to the second end;
• and
• a drug core comprising latanoprost or latanoprost acid disposed in the inner tube,
• wherein the inner casing and outer casing comprise poly(lactic-co-glycolic acid) (PLGA) and the first outer cap comprises poly(vinyl alcohol) (PVA).