Device for Actively Removing a Target Cell from Blood or Lymph of a Vertebrate Subject

A system comprising:

• an implantable device comprising a body defining at least one lumen configured for fluid flow;
• at least one controllable flow barrier to the at least one lumen;
• one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject;
• at least one treatment region disposed within the at least one lumen;
• at least one reactive component disposed in the at least one treatment region, the at least one reactive component configured to modulate the physiological effect of the one or more target cell types in the vertebrate subject;
• and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen;
• wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor.

An implantable device comprising:

• a system including a signal-bearing medium including
• one or more instructions for treatment of a vertebrate subject through a device including one or more instructions for receiving data including data from at least one controllable flow barrier to the at least one lumen;
• one or more instructions for receiving data including data from one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject;
• one or more instructions for receiving data including data from at least one treatment region disposed within the at least one lumen;
• one or more instructions for receiving data including data from at least one reactive component disposed in the at least one treatment region, the at least one reactive component configured to modulate the physiological effect of the one or more target cell types in the vertebrate subject;
• and
• one or more instructions for receiving data including data from at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen;
• wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor.

A system comprising:

• at least one computer program included on a computer-readable recordable-type medium for use with at least one computer system wherein the computer program includes,
• one or more instructions for treatment of a vertebrate subject through a device including one or more instructions for receiving data including data from at least one controllable flow barrier to the at least one lumen;
• one or more instructions for receiving data including data from one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject;
• one or more instructions for receiving data including data from at least one treatment region disposed within the at least one lumen;
• one or more instructions for receiving data including data from at least one reactive component disposed in the at least one treatment region, the at least one reactive component configured to modulate the physiological effect of the one or more target cell types in the vertebrate subject;
• and
• one or more instructions for receiving data including data from at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen;
• wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor.