System, devices, and methods for real-time monitoring of cerebrospinal fluid for markers of progressive conditions
AssigneeSearete LLC, a limited liability corporation of the State of Delaware
InventorsRoderick A. Hyde, Sharon L. Wolda, Lowell L. Wood, JR.
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Abstract
Systems, devices, methods, and compositions are described for providing real-time monitoring of cerebrospinal fluid for markers of progressive conditions.
Claims39
-262. (canceled)
A implantable shunt system, comprising:
- a neuropsychiatric disorder information generation circuit configured to generate neuropsychiatric disorder biomarker information of a cerebrospinal fluid applied to an array;
- and
- a biomarker information comparison circuit configured to generate a comparison between the generated neuropsychiatric disorder biomarker information and user-specific mental disorder filtering information.
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A method, comprising:
- comparing a sensor component output signal of a cerebrospinal fluid received within an indwelling implant and applied to a composition detector to user-specific mental disorder filtering information and
- generating a neuropsychiatric disorder assessment in response to the comparing.
-294. (canceled)
An in vivo method for real-time monitoring of one or more biomarkers within a cerebrospinal fluid, comprising:
- comparing a compositional multiplexed output associated with one or more biomarkers present in a cerebrospinal fluid received with an indwelling implant to user-specific neuropsychiatric disorder information configured as a physical data structure;
- and
- generating a response based on the comparing of the compositional multiplexed output to the user-specific neuropsychiatric disorder information.
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A method for diagnosing schizophrenia, comprising
- detecting, via an indwelling sensor component, time series information associated with a cerebrospinal fluid proximate a surface of the indwelling implant and exposed to a panel of markers;
- and
- generating real-time comparison between the detected time series information and user-specific schizophrenia prodromal marker information or user-specific schizophrenia marker information.
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Dependencies are inferred from the claim text.