Fatty acid acetylated salicylates and their uses
AssigneeCatabasis Pharmaceuticals, Inc.
InventorsJill C. Milne, Michael R. Jirousek, Jean E. Bemis, Jesse J. Smith
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Abstract
The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.
Claims4
A molecular conjugate comprising a salicylate derivative and a fatty acid wherein the fatty acid is selected from the group consisting of omega-3 fatty acids and fatty acids that are metabolized in vivo to omega-3 fatty acids, wherein the conjugate:
- is stable to oral dosing;
- is stable in plasma;
- and
- is capable of enzymatic hydrolysis to produce free salicylate and free fatty acid thereby blunting pro-inflammatory activity and activating anti-inflammatory activity.
Dependencies are inferred from the claim text.