Fluorescent dyes
AssigneeAnaSpec Incorporated
InventorsZhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Abstract
Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
Claims7
A compound of the following structure:
- and its biological salts,
- wherein C is a non-conjugated chain of 10-50 linear atoms selected from a group consisting of carbon, oxygen and nitrogen and wherein C is substituted with substituents selected from a group consisting of hydrogen, an alkyl having 1 to 20 carbons, a hydroxyl, a carbonyl, and RGM;
- R1-R11 and R13-R14 are selected from a group consisting of hydrogen, an alkyl having 1 to 20 carbons, an alkoxy having 1-20 carbons, a trifluoromethyl, a halogen, a methylthio, a sulfonyl, a carbonyl, a hydroxyl, an amino, a thiol or a RGM;
- X is O or S;
- n is 0 to 3;
- wherein RGM is an activated ester, acyl halide, aldehyde, anhydride, carbodiimide, haloacetamide, isocyanate or maleimide.
The compound according to claim 6, wherein R1-R11 and R13-R14 are selected from a group consisting of hydrogen, a halogen, a carbonyl or a RGM.
A compound of the following structure:
- and its biological salts,
- wherein C is a non-conjugated chain of 10-50 linear atoms selected from a group consisting of carbon, oxygen and nitrogen and wherein C is substituted with substituents selected from a group consisting of hydrogen, an alkyl having 1 to 20 carbons, a hydroxyl, a carbonyl, and RGM;
- R1-R11 and R13-R16 are selected from a group consisting of hydrogen, an alkyl having 1 to 20 carbons, an alkoxy having 1-20 carbons, a trifluoromethyl, a halogen, a methylthio, a sulfonyl, a carbonyl, a hydroxyl, an amino, a thiol or a RGM;
- n is 0 to 3;
- wherein RGM is an activated ester, acyl halide, aldehyde, anhydride, carbodiimide, haloacetamide, isocyanate or maleimide.
Dependencies are inferred from the claim text.