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US 2012/0238624 A1Published application
Formulations for the treatment of pain
AssigneeAcorda Therapeutics, Inc.
InventorManoj Maniar
Life of this patent
Estimating the term…
Abstract
Formulations and methods are provided for the treatment of pain, and neuropathic pain in particular. The formulations are eutectic mixtures of a capsaicinoid and a local anesthetic agent and/or an anti-pruritic agent.
Claims39
A substantially nonaqueous therapeutic formulation comprising a binary eutectic mixture of:
- (a) a capsaicinoid having the structure of formula (I)
- wherein R1 is hydrogen, hydroxyl or methoxy, R2 is hydroxyl or C2-C6 alkoxycarbonyl, X is selected from
- and R is selected from C5-C11 alkyl, C5-C11 alkenyl, C11-C23 cis-alkenyl, C11-C23 alkynyl, and C11-C23 alkadienyl;
- and
- (b) a second active agent effective to decrease at least one side effect associated with capsaicin monotherapy, said second agent existing as a solid at 25° C.
2 more elements
A substantially nonaqueous therapeutic formulation comprising a ternary eutectic mixture of:
- (a) a capsaicinoid having the structure of formula (I)
- wherein R1 is hydrogen, hydroxyl or methoxy, R2 is hydroxyl or C2-C6 alkoxycarbonyl, X is selected from
- and R is selected from C5-C11 alkyl, C5-C11 alkenyl, C11-C23 cis-alkenyl, C11-C23 alkynyl, and C11-C23 alkadienyl;
- (b) a second active agent effective to decrease at least one side effect associated with capsaicin monotherapy;
- and
- (c) a third active agent effective to decrease at least one side effect associated with capsaicin monotherapy,
- said second and third active agents both existing as a solid at 25° C.
4 more elements
Dependencies are inferred from the claim text.