Alpha adrenergic receptor modulators
AssigneeAllergan, Inc.
InventorsKen Chow, Liming Wang, Wenkui K. Fang, Evelyn G. Corpuz, Daniel W. Gil
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Abstract
Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor, in particular the alpha 2C receptor. The compounds can include N-(2,3-substituted phenyl)-3,4-dihydro-2H-pyrrol-5-amine derivatives. Methods of making, using and formulating these compounds are described
Claims12
A compound having Formula I
- wherein:
- R1 is selected from methoxy, methyl, chloro, fluoro, bromo;
- and
- R2 is selected from methoxy, methyl, chloro, fluoro, bromo,
- with the proviso that R1 and R2 cannot be methyl in same time.
A pharmaceutical composition, comprising at least one compound selected from:
- N-(2-chlorophenyl)-3,4-dihydro-2H-pyrrol-5-amine;
- N-(2,6-dichlorophenyl)-3,4-dihydro-2H-pyrrol-5-amine;
- N-(2-methylphenyl)-3,4-dihydro-2H-pyrrol-5-amine;
- N-[2-(trifluoromethyl)phenyl]-3,4-dihydro-2H-pyrrol-5-amine;
- N-(2,6-dimethylphenyl)-3,4-dihydro-2H-pyrrol-5-amine;
- N-(2,3-dimethylphenyl)-3,4-dihydro-2H-pyrrol-5-amine.
A method for treating a disorder associated with selective subtype modulation of the alpha 2C adrenergic receptor, comprising administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount of at least one compound having a structure of Formula I
- wherein:
- R1 is selected from methoxy, methyl, chloro, fluoro, bromo;
- and
- R2 is selected from methoxy, methyl, chloro, fluoro, bromo.
A method for treating a disorder associated with selective subtype modulation of the alpha 2C adrenergic receptor, comprising administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount of at least one compound selected from:
- N-(2-chlorophenyl)-3,4-dihydro-2H-pyrrol-5-amine;
- N-(2,6-dichlorophenyl)-3,4-dihydro-2H-pyrrol-5-amine;
- N-(2-methylphenyl)-3,4-dihydro-2H-pyrrol-5-amine;
- N-[2-(trifluoromethyl)phenyl]-3,4-dihydro-2H-pyrrol-5-amine;
- N-(2,6-dimethylphenyl)-3,4-dihydro-2H-pyrrol-5-amine;
- N-(2,3-dimethylphenyl)-3,4-dihydro-2H-pyrrol-5-amine.
Dependencies are inferred from the claim text.