Angiotensin ii receptor antagonists
AssigneeMerck Sharp & Dohme Corp.
InventorsAmjad Ali, Michael Man-chu Lo, Iyassu K. Sebhat, Chris Franklin, Nicoletta Almirante, Silvia Stefanini, Stefano Biondi, Ennio Ongini
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Abstract
A compound having the structure wherein R is, for example, Y is selected from the group consisting of 1) R5, 2) —C(R1R2) (C(R3R4))0-1Y1R5, and 3) —C(R1R2)—O—Y1R5; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is; Y1 is selected from the group consisting of C(O)—O— and P(O)(OR6)—O—; and R6 is hydrogen or CH3, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.
Claims11
A compound having the general formula:
- wherein R is selected from the group consisting of
- Y is selected from the group consisting of
- 1) R5,
- 2) —C(R1R2)(C(R3R4))0-1Y1R5, and
- 3) —C(R1R2)—O—Y1R5,
- R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl;
- and
- R5 is selected from the group consisting of
- Y1 is selected from the group consisting of —C(O)—O— and —P(O)(OR6)—O—;
- and
- R6 is hydrogen or CH3,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.