Cytotoxic compounds
AssigneeMolecular Discovery Systems
InventorRobin Scaife
Life of this patent
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Abstract
The present invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt or solvate or thereof. In particular, the present invention relates to a method treating diseases involving cell proliferation, migration, apoptosis, or adhesion, comprising administering to a human or non-human mammalian patient an effective amount of a compound of general formula (I) or a pharmaceutically acceptable salt or solvate or thereof.
Claims27
A compound of general formula (I) or a pharmaceutically acceptable salt or solvate or thereof:
- wherein:
- R1 is S or O
- R2 is O or NH
- R3 is C or N
- G1 is H or alkyl
- G2,3,4,5 is H, halide, alkyl, alkoxy, cyano, alkylamino, hydroxyl or fused phenyl ring;
- and the carbon-nitrogen double bond is preferably in the E conformation.
A compound selected from the group consisting of:
- or pharmaceutically acceptable salt or solvate thereof or combination thereof.
A compound of general formula (I) or a pharmaceutically acceptable salt or solvate or thereof for use in treating diseases involving cell proliferation, migration, apoptosis, or adhesion.
Use of a compound of general formula (I) or a pharmaceutically acceptable salt or solvate or thereof in the manufacture of a medicament used in treating diseases involving cell proliferation, migration, apoptosis, or adhesion.
A compound of general formula (I) or a pharmaceutically acceptable salt or solvate or hereof:
- wherein:
- A=S or O
- B=O or N
- C or N
- G1=H or alkyl
- G2,3,4,5=H, halide, alkyl, alkoxy, cyano, amino;
- hydroxyl or fused
- phenyl ring
- and the carbon-nitrogen double bond is the E conformation.
A compound selected from the group consisting of:
- or pharmaceutically acceptable salt or solvate thereof or combination thereof.
Dependencies are inferred from the claim text.