Piperidine sulphonamide derivatives
OwnerHenner Knust, Matthias Nettekoven +3inventors
InventorsHenner Knust, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
Life of this patent
Estimating the term…
Abstract
The present invention relates to piperidine sulphonamide derivatives of formula wherein Ar1, Ar2, R1, R2, m and n are as defined in the description and claims, or pharmaceutically suitable acid addition salts thereof. The compounds of formula I are orexin receptor antagonists and the related compounds can be useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder or sleep disorders associated with neurological diseases.
Claims11
A compound of formula I
- wherein
- Ar1 and Ar2 are each independently unsubstituted or substituted aryl or heteroaryl;
- R1 and R2 are each independently hydroxy, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen or cyano;
- m is 0, 1, 2 or 3;
- and
- n is 2;
- or pharmaceutically suitable acid addition salts thereof.
A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I
- wherein
- Ar1 and Ar2 are each independently unsubstituted or substituted aryl or heteroaryl;
- R1 and R2 are each independently hydroxy, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen or cyano;
- m is 0, 1, 2 or 3;
- and
- n is 2;
- or pharmaceutically suitable acid addition salts thereof and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.