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US 2012/0238600 A1Published application
Tropinone benzylamines as beta-tryptase inhibitors
AssigneeSanofi
InventorsYong Mi CHOI-SLEDESKI, Guyan LIANG, Patrick Wai-Kwok SHUM
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Abstract
The present invention discloses and claims a series of substituted tropinone benzylamines of formula (I): The compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted tropinone benzylamines.
Claims8
A compound of formula (I):
- wherein
- R1 is F, Cl, Br, —OCH2CO2CH3, —CH2OH, or an alkyl, haloalkyl, alkoxy or haloalkoxy group;
- and
- R2 is aryl or heteroaryl that is optionally substituted;
- or
- a pharmaceutically acceptable salt thereof or an enantiomer or a diastereomer thereof.
3 more elements
Dependencies are inferred from the claim text.