1H-Pyrrolo[2,3-B]Pyridines

A compound of formula (II),

• wherein:
• Rc is
• wherein:
• A, B, D, and R1a are each independently hydrogen;
• OR;
• CN;
• halogen;
• CO2R;
• CONR1R2;
• NR1R2;
• NR3R4;
• S(O)n(C1-6)alkyl wherein said alkyl is unsubstituted or substituted with 1-3 substituents selected from the group consisting of halogen;
• OR;
• NRR′;
• and CN;
• aryl;
• heteroaryl;
• (C1-3)alkyl-NR1R2;
• (C1-6)alkyl;
• or (C1-6)haloalkyl;
• X and Y are each independently CR1a or N;
• Z is NR, O or S;
• Rd is
• M is independently hydrogen;
• (C1-3)alkyl-NR1R2;
• (C1-3)alkyl-OR;
• halogen;
• CO2R;
• OR;
• S(O)n(C1-6)alkyl wherein said alkyl is unsubstituted or substituted with 1-3 substituents selected from the group consisting of halogen;
• OR;
• NRR′;
• and CN);
• NR1R2;
• (C1-3)alkyl-NR3R4;
• SO2NR1R2;
• (C1-3)alkyl-SO2NR1R2;
• CONR1R2;
• (C1-6)alkyl-CONR1R2;
• CHO;
• (C1-6)alkylCO2R;
• (C1-6)alkyl;
• and NR3R4;
• M′ is independently hydrogen;
• (C1-3)alkyl-NR1R2;
• (C1-3)alkyl-OR;
• halogen;
• CO2R;
• OR;
• S(O)n(C1-6)alkyl wherein said alkyl is unsubstituted or substituted with 1-3 substituents selected from the group consisting of halogen;
• OR;
• NRR′;
• and CN);
• NR1R2;
• (C1-3)alkyl-NR3R4;
• SO2NR1R2;
• (C1-3)alkyl-SO2NR1R2;
• CONR1R2;
• (C1-6)alkyl-CONR1R2;
• CHO;
• (C1-6)alkylCO2R;
• NR3R4;
• (C1-6)alkyl;
• and phenyl;
• P and Q are each independently hydrogen;
• halogen;
• (C1-6)alkyl;
• (C1-3)alkylOR;
• (C1-6)haloalkyl;
• CO2R;
• CHO;
• S(O)n(C1-6)alkyl wherein said alkyl is unsubstituted or substituted with 1-3 substituents selected from the group consisting of halogen;
• OR;
• NRR′;
• and CN);
• (C1-6)alkyl-CO2R;
• (C1-3)alkyl-NR1R2;
• (C1-3)alkyl-NR3R4;
• OR;
• NR1R2;
• NR3R4;
• CONR1R2;
• (C1-6)alkyl-CONR1R2;
• SO2NR1R2;
• (C1-3)alkyl-SO2NR1R2;
• aryl;
• and heteroaryl;
• T, U, V and W are each independently hydrogen;
• halogen;
• (C1-6)alkyl;
• (C1-3)alkylOR;
• (C1-6)haloalkyl;
• CO2R;
• CHO;
• S(O)n(C1-6)alkyl wherein said alkyl is unsubstituted or substituted with 1-3 substituents selected from the group consisting of halogen;
• OR;
• NRR′;
• and CN);
• (C1-6)alkyl-CO2R;
• (C1-3)alkyl-NR1R2;
• (C1-3)alkyl-NR3R4;
• OR;
• NR1R2;
• NR3R4;
• CONR1R2;
• (C1-6)alkyl-CONR1R2;
• SO2NR1R2;
• (C1-3)alkyl-SO2NR1R2;
• aryl;
• and heteroaryl;
• R and R′ are independently at each occurrence hydrogen;
• (C1-3)alkylaryl;
• (C1-3)alkylheteroaryl;
• (C1-6)alkyl;
• or (C1-6)haloalkyl;
• R1 and R2 are independently at each occurrence hydrogen;
• (C1-6)alkyl;
• (C1-3)alkylNRR′;
• (C1-3)alkylOR;
• (C1-6)cyanoalkyl;
• NRR′;
• (C1-3)alkylaryl, (C1-3)alkylheteroaryl;
• (C1-6)haloalkyl;
• or together with the nitrogen that they are attached form a 4, 5, 6, or 7 member non-aromatic ring, said ring optionally containing up to 2 additional heteroatoms selected from the group consisting of NR;
• O;
• or S(O)n;
• and said ring being unsubstituted or substituted with from 1-3 substituents selected from the group consisting of halogen;
• (C1-6)alkyl;
• OR;
• NRR′;
• CN;
• halogen;
• (C1-6)haloalkyl;
• phenyl;
• heteroaryl or heterocyclyl;
• n is independently at each occurrence 0, 1 or 2;
• R3 is independently at each occurrence hydrogen;
• (C1-6)alkyl;
• or (C1-6)haloalkyl;
• R4 is C(═O)(C1-6)alkyl;
• C(═O)(C1-3)alkyl-NRR′;
• C(═O)—(C1-3)alkylaryl wherein said aryl is unsubstituted or substituted with 1-3 substituents selected from halogen, (C1-3)alkyl and C1-3alkoxy);
• C(═O)—(C1-3)alkylheteroaryl;
• S(O)n(C1-6)alkyl;
• SO2NR1R2;
• C(═O)-phenyl wherein the phenyl group is unsubstituted or substituted with 1-3 substituents selected from the group consisting of halogen, (C1-6)alkyl and OR;
• or a pharmaceutically acceptable salt or solvate thereof;
• and
• provided at least one of M, P, and Q is (C1-6)alkyl-CO2R or (C1-6)alkyl-CONR1R2;
• and
• provided at least one of U and V, or at least one of U, V, T and W is (C1-6)alkyl-CO2R or (C1-6)alkyl-CONR1R2.

A compound selected from the group consisting of:

• a) 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid;
• b) {3-[5-(2-naphthyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzyl}amine;
• c) 4-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• d) {4-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• e) 3-{4-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• f) {3-[5-(2-naphthyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}methanol;
• g) 4-{5-[3-(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• h) 3-(4-{5-[3-(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)propanoic acid;
• i) 3-{3-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}benzonitrile;
• j) 4-{5-[3-(aminocarbonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• k) 4-[5-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• l) 4-{5-[6-(methyloxy)-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• m) 3-{3-[3-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}benzonitrile;
• n) 4-[5-(1-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• o) 2-fluoro-4-[5-(1-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• p) 3-amino-5-[5-(1-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• q) 3-{4-[5-(1-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• r) 3-(4-{5-[3-(aminocarbonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)propanoic acid;
• s) 3-{4-[5-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• t) 3-(4-{5-[6-(methyloxy)-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)propanoic acid;
• u) {4-[5-(1-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• v) (4-{5-[3-(aminocarbonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)acetic acid;
• w) {4-[5-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• x) (4-{5-[6-(methyloxy)-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)acetic acid;
• y) 3-{4-[5-(3-Methanesulfonylamino-phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenyl}-propionic acid;
• z) {4-[5-(3-Methanesulfonylamino-phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenyl}-acetic acid;
• aa) 3-{4-[5-(3-Methanesulfonyl-phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenyl}-propionic acid;
• ab) {4-[5-(3-Methanesulfonyl-phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenyl}-acetic acid;
• ac) 3-[3-fluoro-4-(methyloxy)phenyl]-5-phenyl-1H-pyrrolo[2,3-b]pyridine;
• ad) 5-phenyl-3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridine;
• ae) 3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid;
• af) N-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl]-acetamide;
• ag) 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenylamine;
• ah) 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenol;
• ai) 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamine;
• aj) 3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenol;
• ak) 5-(3,4-dimethoxyphenyl)-3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridine;
• al) 4-[5-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-yl]-phenol;
• am) 4-[5-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-yl]-phenylamine;
• an) 4-[5-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzoic acid;
• ao) 4-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzoic acid;
• ap) N-[4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl]-acetamide;
• aq) 3,5-bis-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine;
• ar) 3,5-bis-(4-carboxyphenyl)-1H-pyrrolo[2,3-b]pyridine;
• as) 4-[5-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamine;
• at) 4-[5-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid;
• au) 4-[5-(2-fluoro-biphen-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid;
• av) N-[3-(5-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl]-acetamide;
• aw) 4-(5-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid;
• ax) 4-(5-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenol;
• ay) 4-(5-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzamide;
• az) N-[3-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl]-acetamide;
• ba) 4-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid;
• bb) 4-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenol;
• bc) 4-(5-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzylamine;
• bd) 3-(1H-indol-5-yl)-5-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridine;
• be) N-[4-(5-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl]-acetamide;
• bf) 5-(3-pyridinyl)-3-(4-pyridinyl)-1H-indole;
• bg) 4-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzamide;
• bh) 4-[3-(2-fluorobiphenyl-4-yl-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzylamine;
• bi) 4-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenylamine;
• bj) {3-[5-(4-methanesulfonylphenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenyl}-acetic acid;
• bk) N-[3-(3-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridin-5-yl)-phenyl]-acetamide;
• bl) N-{3-[3-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl}acetamide;
• bm) 4-[5-(3-acetylaminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzoic acid;
• bn) N-{3-[3-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-phenyl}-acetamide;
• bo) N-{3-[3-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-phenyl}-acetamide;
• bp) N-{3-[3-(4-aminomethylphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-phenyl}-acetamide;
• bq) N-{3-[3-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-phenyl}-acetamide;
• br) N-{3-[3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl}-acetamide;
• bs) 4-[3-(2-fluorobiphenyl-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoic acid;
• bt) N-{3-[3-(4-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl}acetamide;
• bu) N-{3-[5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenyl}-acetamide;
• by) 4-[5-(3-acetylaminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide;
• bw) 4-[5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzoic acid;
• bx) 4-[5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenylamine;
• by) N-{4-[5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenyl}-acetamide;
• bz) 4-[5-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide;
• ca) 2-chloro-N-[4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl]-benzamide;
• cb) 2-phenyl-N-[4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl]-acetamide;
• cc) 2-chloro-N-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzyl]-benzamide;
• cd) 2-phenyl-N-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzyl]-acetamide;
• ce) (4-{5-[3-(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)acetic acid;
• cf) 3-[4-(5-{4-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanoic acid;
• cg) [4-(5-{4-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid;
• ch) (4-{5-[3,4,5-tris(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)acetic acid;
• ci) 3-(4-{5-[3,4,5-tris(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)propanoic acid;
• cj) {4-[5-(6-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• ck) 3-{4-[5-(6-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• cl) {4-[5-(3-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• cm) {4-[5-(5-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• cn) 3-{4-[5-(5-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• co) 3-(4-{5-[6-(methyloxy)-2-naphthalenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)propanoic acid;
• cp) 3-{4-[5-(3,4-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• cq) {4-[5-(3,4-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• cr) {4-[5-(2,3-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• cs) 3-{4-[5-(2,3-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• ct) {4-[5-(2,3-dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• cu) 3-{4-[5-(2,3-dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• cv) {4-[5-(1-benzothien-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• cw) [(3-{5-[3-(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)methyl]amine;
• cx) 7-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1,2,3,4-tetrahydroisoquinoline;
• cy) 2-fluoro-4-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• cz) 2-fluoro-4-{5-[3-(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• da) 2-methyl-4-{5-[3-(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• db) 5-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-thiophenecarbaldehyde;
• dc) 5-{5-[3-(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-thiophenecarbaldehyde;
• dd) 2-methyl-4-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• de) (4-{5-[6-(methyloxy)-2-naphthalenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)acetic acid;
• df) 2-fluoro-4-{5-[6-(methyloxy)-2-naphthalenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• dg) 2-fluoro-4-[5-(5-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• dh) 4-[5-(5-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• di) 2-methyl-4-[5-(5-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• dj) 4-[5-(3,4-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• dk) 4-[5-(3,4-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-fluorobenzoic acid;
• dl) 4-[5-(3,4-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methylbenzoic acid;
• dm) 4-[5-(2,3-dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• dn) 4-[5-(2,3-dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methylbenzoic acid;
• do) 4-[5-(1-benzothien-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• dp) 4-[5-(1-benzothien-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-fluorobenzoic acid;
• dq) 4-[5-(1-benzothien-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methylbenzoic acid;
• dr) 6-{3-[4-(ethylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}quinoline;
• ds) 4-(5-{3-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• dt) 3-[4-(butyloxy)phenyl]-5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridine;
• du) N-(3-{3-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}phenyl)methane sulfonamide;
• dv) N-(3-{3-[3-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}phenyl)methane sulfonamide;
• dw) 3-amino-5-(5-{3-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• dx) 2-fluoro-4-(5-{3-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• dy) 3-amino-5-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• dz) 2-fluoro-4-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• ea) [(4-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)methyl]amine;
• eb) [(3-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)methyl]amine;
• ec) 5-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-thiophenecarbaldehyde;
• ed) 4-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• ee) N-(4-{3-[4-(butyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}phenyl)methanesulfonamide;
• ef) 1,1-dimethylethyl[2-(3-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)ethyl]carbamate;
• eg) 3-amino-5-(5-{4-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• eh) 2-fluoro-4-(5-{4-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• ei) 4-(5-{4-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• ej) N-(4-{3-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}phenyl)methane sulfonamide;
• ek) N-(4-{3-[3-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}phenyl)methane sulfonamide;
• el) N-{4-[3-(5-formyl-2-thienyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methanesulfonamide;
• em) 7-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-1,2,3,4-tetrahydroisoquinoline;
• en) N-{3-[3-(1,2,3,4-tetrahydro-7-isoquinolinyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methanesulfonamide;
• eo) N-{4-[3-(1,2,3,4-tetrahydro-7-isoquinolinyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methanesulfonamide;
• ep) 2-methyl-4-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• eq) 5-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-thiophenecarboxylic acid;
• er) 3-{3-[3-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}benzonitrile;
• es) 2-fluoro-4-{5-[6-(methyloxy)-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• et) 3-[3-(1,2,3,4-tetrahydro-7-isoquinolinyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]benzonitrile;
• eu) 7-{5-[3,4,5-tris(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-1,2,3,4-tetrahydroisoquinoline;
• ev) 4-{5-[3,4,5-tris(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• ew) 2-fluoro-4-{5-[3,4,5-tris(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• ex) 2-amino-4-{5-[3,4,5-tris(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• ey) 4-[5-(6-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• ez) 4-[5-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-fluorobenzoic acid;
• fa) 4-[5-(2,3-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• fb) 4-[5-(2,3-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-fluorobenzoic acid;
• fc) 2-methyl-4-[5-(6-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• fd) 2-methyl-4-[5-(1-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• fe) 4-[5-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methylbenzoic acid;
• ff) 2-methyl-4-{5-[6-(methyloxy)-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• fg) 2-methyl-4-{5-[3,4,5-tris(methyloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• fh) 2-(1-methylethyl)-4-[5-(1-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• fi) 4-[5-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-(1-methylethyl)benzoic acid;
• fj) 2-(1-methylethyl)-4-[5-(6-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• fk) 4-[5-(2,3-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methylbenzoic acid;
• fl) 2-chloro-4-{5-[3-(methylsulfonyl)phenyl]-1-H-pyrrolo-[2,3-b]pyridin-3-yl}benzoic acid;
• fm) 4-{5-[3-(methylsulfonyl)phenyl]-1-H-pyrrolo-[2,3-b]pyridin-3-yl}-2,6-bis(trifluoromethyl)benzoic acid;
• fn) methyl 2-(azidomethyl)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoate;
• fo) 2-ethyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• fp) 2-(methylamino)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• fq) 2-(dimethylamino)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• fr) 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• fs) 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propylbenzoic acid;
• ft) 2,6-difluoro-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• fu) 2,6-dimethyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• fv) 2-(2-propyl)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• fw) 6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indazole;
• fx) 2-(2-methylpropyl)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• fy) 2-methyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• fz) 4-[5-(3-hydroxyphenyl)-1-H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• ga) 3-amino-5-[5-(3-hydroxyphenyl)1H-pyrrolo[2,3-b]pyridin-3-yl]-benzoic acid;
• gb) {4-[5-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-phenyl}acetic acid;
• gc) 4-[5-(3-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• gd) 3-{4-[5-(3-hydroxyphenyl)-1-H-pyrrolo[2,3-b]pyridine-3-yl]-phenyl}-propionic acid;
• gd) 3-{4-[5-(3-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• gf) {4-[5-(3-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid;
• gg) 4-{5-[3-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• gh) (4-{5-[3-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)acetic acid;
• gi) 4-[5-(3-hydroxyphenyl)-1-H-pyrrolo-[2,3-b]pyridin-3-yl]benzoic acid;
• gj) 2-fluoro-4-[5-(3-hydroxyphenyl)-1-H-pyrrolo-[2,3-b]pyridin-3-yl]benzoic acid;
• gk) 5-[5-(3-hydroxyphenyl)-1-H-pyrrolo-[2,3-b]pyridin-3-yl]thiophene-2-carbaldehyde;
• gl) 3-{3-[3-(2-aminoethyl)phenyl]-1-H-pyrrolo-[2,3-b]pyridin-5-yl}phenol;
• gm) 3-[3-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-H-pyrrolo-[2,3-b]pyridin-5-yl]phenol;
• gn) 3-amino-5-[5-(3-aminophenyl)-1-H-pyrrolo-[2,3-b]pyridin-3-yl]benzoic acid;
• go) 4-[5-(3-aminophenyl)-1-H-pyrrolo-[2,3-b]pyridin-3-yl]-2-fluorobenzoic acid;
• gp) 2-fluoro-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenol;
• gq) 2,6-difluoro-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenol;
• gr) 5-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine;
• gs) 5-(2-naphthalenyl)-3-[4-(1H-tetrazol-5-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine;
• gt) 3-[3-fluoro-4-(1H-tetrazol-5-yl)phenyl]-5-phenyl-1H-pyrrolo[2,3-b]pyridine;
• gu) 2-methyl-2-(4-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)propanoic acid;
• gv) 2-{4-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• gw) 2-(4-{5-[3-(aminocarbonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-2-methylpropanoic acid;
• gx) 2-{4-[5-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}-2-methylpropanoic acid;
• gy) 2-methyl-2-{4-[5-(6-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• gz) 2-methyl-2-{4-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• ha) 2-methyl-2-[4-(5-{3-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanoic acid;
• hb) 2-methyl-2-[4-(5-{4-[(methylsulfonyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanoic acid;
• hc) 2-methyl-2-(4-{5-[6-(methyloxy)-2-naphthalenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)propanoic acid;
• hd) 2-methyl-2-{4-[5-(5-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• he) 2-methyl-2-{4-[5-(3-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• hf) 2-{4-[5-(6-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• hg) 2-{4-[5-(5-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• hh) 2-{4-[5-(3-quinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• hi) 2-(4-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)propanoic acid;
• hj) 2-(4-{5-[6-(methyloxy)-2-naphthalenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)propanoic acid;
• hk) 2-methyl-2-[4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanoic acid;
• hl) 2-methyl-2-{4-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}propanoic acid;
• hm) 4-[5-(6-amino-3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• hn) 4-{5-[6-(-alanylamino)-3-pyridinyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• ho) 4-(5-(6-indolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• hp) [2-(3-{5-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)ethyl]amine;
• hq) N-(3-{3-[3-(2-aminoethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}phenyl)methanesulfonamide;
• hr) N-(4-{3-[3-(2-aminoethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}phenyl)methanesulfonamide;
• hs) 4-{5-[3-(2-aminoethyl)phenyl]-1-H-pyrrolo-[2,3-b]pyridin-3-yl}benzoic acid;
• ht) 4-{5-[3-(2-aminoethyl)phenyl]-1-H-pyrrolo-[2,3-b]pyridin-3-yl}-2-methylbenzoic acid;
• hu) 4-{5-[3-({[2-(dimethylamino)ethyl]amino}carbonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• hv) 4-(5-(3-[4-(1,1-dimethylethyloxycarbonyl)aminobutanoyl]amino)phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• hw) 4-(5-(3-[3-(1,1-dimethylethyloxycarbonyl)aminopropanoyl]amino)phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• hx) 2-(2-propyl)-4-[5-[3-[3-(1,1-dimethylethyloxycarbonyl)aminopropanoyl]amino)phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• hy) 4-{5-[3-(-alanylamino)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid;
• hz) 4-(5-{3-[(4-aminobutanoyl)amino]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• ia) 4-{5-[3-(beta-alanylamino)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-methylbenzoic acid;
• ib) 4-{5-[3-(beta-alanylamino)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-(1-methylethyl)benzoic acid;
• ic) 4-[5-(3-{[(2-aminoethyl)amino]carbonyl}phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• id) 4-[5-(3-{[(3-aminopropyl)amino]carbonyl}phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid;
• ie) 3-amino-5-[5-(3-aminophenyl)-1-H-pyrrolo-[2,3-b]pyridin-3-yl]benzoic acid;
• if) 3-amino-5-{5-[3-(aminomethyl)phenyl]-1-H-pyrrolo-[2,3-b]pyridin-3-yl}benzoic acid;
• ig) 4-{5-[3-(aminomethyl)phenyl]-1-H-pyrrolo-[2,3-b]pyridin-3-yl}-2-fluorobenzoic acid;
• ih) 2-(aminomethyl)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid;
• ii) 3-{3-[3-(2-aminoethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}benzonitrile;
• and
• ij) 4-[5-(3-amino-1-isoquinolinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-fluorobenzoic acid;
• or a pharmaceutically acceptable salt or solvate thereof.