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US 2012/0238587 A1Published application
Novel pyridopyrimidine derivatives and use thereof
AssigneeChemizon, A Division of Optomagic Co., Ltd.
InventorsGilnam Lee, Chul Soo Lim, Han Won Cho, Jeongbeob Seo, Albert Charles Gyorkos, Suk Young Cho, Eun Kyung Choi, Choung Soo Kim, Jung Jin Hwang
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Abstract
The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of the phosphoinositide 3′ OH kinase family (PI3K) for the treatment of inflammatory diseases, cancer, cardiovascular diseases, allergy, asthma and autoimmune disorders.
Claims7
A compound of formula I,
- Wherein X is C or O or N or S;
- Y is C or N;
- R1 is selected from the group consisting of acyl, amino, substituted amino, C1-C6alkyl, substituted C1-C6alkyl, C3-C7cycloalkyl, substituted C3-C7cycloalkyl, C3-C7heterocycloalkyl, substituted C3-C7 heterocycloalkyl, alkylcarboxy, arylamino, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, arylcycloalkyl, substituted arylcycloalkyl, heteroarylalkyl, substituted heteroarylalkyl, cyano, nitro;
- R2 is selected from the group consisting of hydrogen, halogen, acyl, amino, substituted amino, C1-C6alkyl, substituted C1-C6alkyl, C3-C7cycloalkyl, substituted C3-7 Ccycloalkyl, C3-7Cheterocycloalkyl, substituted C3-C7heterocycloalkyl, alkylcarboxy, arylamino, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, arylcycloalkyl, substituted arylcycloalkyl, heteroarylalkyl, substituted heteroarylalkyl, cyano, nitro, alkoxy, C3-C7cycloalkyloxy, substituted C3-C7cycloalkyloxy, C3-C7heterocycloalkyloxy, substituted C3-7Cheterocycloalkyloxy, acyloxy, aryloxy;
- R3═NR4′SO2R4, SO2NR4′R4, NR4′COR4, CONR4′R4, NR4′CONHR4;
- R4 is selected from the group consisting of alkyl, substituted alkyl, amino, halo, C3-C7cycloalkyl, substituted C3-C7cycloalkyl, C3-C7heterocycloalkyl, substituted C3-C7heterocycloalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl;
- R4′ is H or C1-C6 alkyl;
- R5 is selected from the group consisting of hydrogen, halogen, C1-C6alkyl;
- R6 is selected from the group consisting of hydrogen, halogen, acyl, alkoxy, amino, substituted amino, arylamino, C1-C6alkyl, substituted C1-C6 alkyl, C3-C7cycloalkyl, substituted C3-C7cycloalkyl, C3-C7heterocycloalkyl, substituted C3-C7heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
- n is 0 or 1;
- m is 0 or 1;
- and/or a pharmaceutically acceptable salt, solvate, polymorph, tautomer or prodrug thereof.
9 more elements
Dependencies are inferred from the claim text.