Quinazoline derivatives

Compounds of the formula I

• in which
• R1, R2 each, independently of one another, denote H, A, (CH2)nHet or (CH2)nAr,
• R1 and R2, together with the N atom to which they are bonded, also denote a saturated, unsaturated or aromatic mono- or bicyclic heterocycle, which may contain a further 1 to 3 N, O and/or S atoms and which is unsubstituted or mono-, di- or trisubstituted by Hal, A, (CH2)nHet, (CH2)nAr, (CH2)nOH, (CH2)nOA, (CH2)nNH2, (CH2)nCOOH, (CH2)nCOOA, NHCOA, NA′COA, CONH2, CONHA, CONAA′, OC(═O)(CH2)pNH2 and/or ═O (carbonyl oxygen),
• R3, R4 each, independently of one another, denote H, Hal, A, (CH2)nHet, (CH2)nAr, (CH2)nCOHet or (CH2)nC(═CH2)CONR5R6,
• R3 and R4, together with the C atom to which they are bonded, also denote a saturated or unsaturated monocyclic C3-C10-carbocycle, which may contain a further 1 to 3 N, O and/or S atoms and which is unsubstituted or mono-, di- or trisubstituted by Hal, A, (CH2)nOH, (CH2)nOA, (CH2)nNH2, (CH2)nCOOH, (CH2)nCOOA, NHCOA, NA′COA, CONH2, CONHA, CONAA′, OC(═O)(CH2)pNH2 and/or ═O (carbonyl oxygen),
• X denotes NR5R6, CONR5R6, CH2NR5R6, COOR5, —OR5, CH2OR5, COHet, Het, CONH(CH2)pCN or CONH(CH2)pNR5R6,
• R5, R6 each, independently of one another, denote H, A, (CH2)nHet or (CH2)nAr,
• Ar denotes phenyl, naphthyl, tetrahydronaphthyl or biphenyl, each of which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by A, Hal, (CH2)nOA, (CH2)nOH, (CH2)nCN, SA, SOA, SO2A, NO2, C≡CH, (CH2)nCOOH, CHO, (CH2)nCOOA, CONH2, CONHA, CONAA′, NHCOA, CH(OH)A, (CH2)nNH2, (CH2)nNHA, (CH2)nNAA′, (CH2)nNHSO2A, SO2NH(CH2)nNH2, SO2NH2, SO2NHA, SO2NAA′, CONH(CH2)nCOOA, CONH(CH2)nCOOH, NHCO(CH2)nCOOA, NHCO(CH2)nCOOH, CONH(CH2)nNH2, CONH(CH2)nNHA, CONH(CH2)nNAA′, CONH(CH2)nCN and/or (CH2)nCH(NH2)COOH,
• Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by A, OA, OH, phenyl, SH, S(O)mA, Hal, NO2, CN, COA, COOA, COObenzyl, CONH2, CONHA, CONAA′, SO2NH2, NH2, NHA, NAA′, NHCOA, NHSO2A and/or ═O (carbonyl oxygen),
• A, A′ each, independently of one another, denote unbranched or branched alkyl having 1-10 C atoms, in which 1-3 non-adjacent CH2 groups may be replaced by O, S, SO, SO2, NH, NMe or Net, and/or, in addition, 1-5H atoms may be replaced by F and/or Cl,
• or cyclic alkyl having 3-8 C atoms,
• Hal denotes F, Cl, Br or I,
• n denotes 0, 1, 2, 3 or 4,
• p denotes 1, 2, 3 or 4,
• and pharmaceutically usable salts and stereoisomers thereof, including mixtures thereof in all ratios.