Prostaglandin transporter inhibitors and uses thereof

A compound having the structure:

• wherein
• W is O or NR5;
• R1 is H, —CH3, —(CH2)2OH,
• R2 is
• R3 is —(CH2)5CH3, —(CH2)6CO2H, —(CH2)6CO2CH3, —(CH2)dNHCO-Ph, —(CH2)6CONH-Ph, —(CH2)6CONHCH2-Ph,
• R4 and R5 are independently H or —CH3;
• R6 is O or NR9;
• R7 is H, —CH3, —C(CH3)3, —CH2OH, —(CH2)2OH, —(CH2)2—O—(CH2)2OH, (CH2CH2O)3CH3, (CH2CH2O)2CH2CO2CH3, (CH2)5CH3,
• R8 is H, —OH, —CH2OH, —CO2H, —CO2CH2CH3, —CO(CH2)6CH3, —OCH3, —NH2, —SO2NH2, —CONH-Bn or
• R9 is H or —CH3;
• R10 is —CH2NH2, —CO2H or —CO2CH3;
• R11 is —SO2-Ph, —CH2-Ph, —CONH-Ph, —COCH3,
• and
• R12 is —CH3,
• where X1, X2, X3, X4, X5, X6 and X7 are independently H, halogen, —OH, —CH3, —CF3, —OCH3, —CO2H, —CO2CH3, —CH2CO2H, —CH2CO2CH3, phenyl or —O-Bn;
• and
• where a=0-2;
• b=1-6;
• c=0-1;
• d=4-7;
• and e=0-1;
• or a pharmaceutically acceptable salt thereof.