Antiproliferative pyrimidyl, fused pyrimidyl and pyrimidyl hydrazones

A compound according to Formula (I)

• wherein
• A is selected from the group consisting of A1, A2, A3, A4 and A5:
• wherein each X is independently selected from the group consisting of CR6, N and NR6;
• and each Y is independently selected from the group consisting of CR6, N, NR6, S and O;
• L is either a bond or NR6;
• R1, R6 and R9 are independently either hydrogen or C1-C6-alkyl;
• each R2 is independently selected from the group consisting of hydrogen, halogen, cyano, thioamide, acyl, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, sulfonylamine, halo-C1-C6-alkyl, C1-C6-alkoxy, hydroxylamine, hydroxyl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, aryl and heteroaryl;
• n is an integer selected from 1, 2, 3, 4 or 5;
• R3 and R7 are independently selected from the group consisting of hydrogen, halogen, cyano, thiourea, acylamine, carboxy, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, sulfonylamine, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, hydroxylamine, hydroxyl, aryl and heteroaryl, wherein each of said C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, sulfonylamine, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, hydroxylamine, hydroxyl, aryl and heteroaryl is optionally substituted with one or more substituents selected from the group consisting of halogen, amine, cyano, C1-C6-alkyl, C2-C6-alkenyl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, sulfonylamine, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, hydroxyl, acylamine, hydroxy-C1-C6-alkyl, aryl and heteroaryl;
• R5 is selected from the group consisting of hydrogen, halogen, cyano, thiourea, amino, acylamine, carboxy, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, sulfonylamine, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, hydroxylamine, hydroxyl, aryl and heteroaryl, wherein each of said C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, sulfonylamine, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, hydroxylamine, hydroxyl, aryl and heteroaryl is optionally substituted with one or more substituents selected from the group consisting of halogen, amine, cyano, C1-C6-alkyl, C2-C6-alkenyl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, sulfonylamine, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, hydroxyl, acylamine, hydroxy-C1-C6-alkyl, aryl and heteroaryl;
• R4 is selected from the group consisting of C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, aryl and heteroaryl bonded through a ring carbon, wherein each of said C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, aryl and heteroaryl bonded through a ring carbon is optionally substituted with one or more substituents selected from the group consisting of halogen, amine, cyano, C1-C6-alkyl, C2-C6-alkenyl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, sulfonylamine, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, hydroxyl, aminocarbonyl, acylamine, hydroxy-C1-C6-alkyl, aryl and heteroaryl;
• and
• and geometrical isomers, enantiomers, diastereomers, tautomers, racemates or pharmaceutically acceptable salts thereof.