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US 2012/0238569 A1Published application
Thiazole and thiophene compounds
AssigneeHoffmann-La Roche Inc.
InventorsPaul Gillespie, Christophe Michoud, Kenneth Carey Rupert, Kshitij Chhabilbhai Thakkar
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Abstract
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
Claims24
A compound of formula (I):
- wherein:
- X is N or CH;
- R1 is indole, oxoindole, indazole or substituted phenyl, said substituted phenyl being mono- or bi-substituted independently with hydroxy, halogen, alkoxy or lower alkyl;
- R2 is —(CH2)nC(O)NH—, —(CH2)nNHC(O)—, —(CH2)nNH—, —(CH2)nO— or —CH(CH3)NHC(O)—;
- R3 is hydrogen, methyl, trifluoromethyl, halogen or cyano;
- R4 is indazole, benzimidazole, unsubstituted heteroaryl, heteroaryl mono- or bi-substituted independently with (═O), alkoxy or hydroxy, unsubstituted phenyl or phenyl mono- or bi-substituted independently with hydroxy, methyl, halogen or —COOH;
- R5 is hydrogen, lower alkyl, alkoxy, cycloalkyl, heterocycloalkyl, lower alkyl-cycloalkyl, lower alkyl-heterocycloalkyl, —(CH2)nOR6, —CH(CH3)O(O)R6 or —(CH2)—NR7R8;
- R6, R7 and R8, independently of each other, are hydrogen, lower alkyl or alkoxy;
- and
- n is 1, 2 or 3,
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.