Use of cell autophagy (type ii cell apoptosis) inhibitors
OwnerChengyu Jiang, Shuan Rao +5inventors
InventorsChengyu Jiang, Shuan Rao, Haolin Liu, Feng Guo, Hongliang Wang, Yang Sun, Chenggang Li
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Abstract
Use of cell autophagy (type II cell apoptosis) inhibitors for preventing and/or treating avian influenza, injury of lungs caused by avian influenza virus or nanometer materials. The cell autophagy (type II cell apoptosis) inhibitors are selected from 3-methyladenine, SB203580, LY294002, and or wortmannin. The injury of lungs includes acute respiratory distress syndrome. The avian influenza virus is H5N1, H5N2 or H9N2 avian influenza virus. The nanometer materials include PAMAM G3, G4, G5, G5.5, G6, G7, or G8.
Claims19
A composition for use in at least one of preventing treating avian influenza of mammals, the composition comprising:
- an inhibitor of autophagy (type II programmed cell death) selected from 3-methyladenine, SB203580, LY294002, and wortmannin.
A composition of inhibitor of autophagy (type II PCD) for use in at least one of preventing treating lung injury of mammals induced by nanometer materials, the composition comprising:
- an inhibitor of autophagy (type II PCD) is selected from 3-methyladenine, SB203580, LY294002 and wortmannin.
A method for preventing and/or treating an influenza of mammals, the method comprising:
- administering an effective amount of an inhibitor of autophagy (type II PCD) to a mammal, the effective amount causing at least one or prevention and treatment of the influenza, the inhibitor being selected from 3-methyladenine, SB203580, LY294002, and wortmannin.
A method for preventing and/or treating a lung injury of mammals induced by nanometer materials, the method comprising:
- administering an effective amount of an inhibitor of autophagy (type II PCD) to a mammal, the effective amount causing at least one or prevention and treatment of the lung injury of mammals induced by nanometer materials, the inhibitor being selected from 3-methyladenine, SB203580, LY294002 and wortmannin.
Dependencies are inferred from the claim text.