Morpholinothiazoles as alpha 7 positive allosteric modulators

A compound having the formula (I)

• or a stereochemical isomer thereof, wherein
• R1 is C1-6alkyl, C1-6alkyl substituted with 1, 2 or 3 halogen substituents, C1-6alkyl substituted with 1 cyano group, C1-6alkyl substituted with 1 heteroaryl group,
• C3-6cycloalkyl, C3-6cycloalkyl substituted with 1, 2, 3, or 4 methyl groups,
• C3-6cycloalkyl substituted with 1 hydroxy group, (C3-6cycloalkyl)C1-6alkyl, (C1-6alkyloxy)C1-6alkyl, (haloC1-4alkyloxy)C1-6alkyl, tetrahydrofuryl, aryl, heteroaryl, pyrrolidinyl, pyrrolidinyl substituted with 1 C1-4alkyl group,
• or tetrahydrofuryl substituted with 1, 2 or 3 substituents selected from methyl and oxo;
• aryl is 2,2-difluoro-1,3-benzodioxolyl;
• phenyl;
• or phenyl substituted with 1, 2 or 3 substituents selected from halogen, trifluoromethyl, trifluoromethoxy, cyano, C1-6alkyl, C1-4alkyloxy, and aminosulfonyl;
• heteroaryl is a mono- or bicyclic aromatic heterocyclic radical containing at least one heteroatom selected from N, O and S, optionally substituted with 1, 2 or where possible with 3 substituents selected from C1-4alkyl, C1-4alkyloxy, C3-6cycloalkyl, and trifluoromethyl;
• R2 and R3 are independently H, C1-4alkyl or trifluoromethyl;
• or R2 and R3 are taken together to form 1,2-ethanediyl or 1,3-propanediyl;
• Ar is
• R4 and R5 are independently H, C1-4alkyl, trifluoromethyl, C3-6cycloalkyl or C1-4alkyloxy;
• or an acid addition salt thereof.