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US 2012/0238560 A1Published application
Oxazine Derivatives and their Use in the Treatment of Neurological Disorders
AssigneeNovartis AG
InventorsPhilipp HOLZER, Rainer MACHAUER, Marina TINTELNOT-BLOMLEY
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Abstract
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
Claims4
A method for the treatment or prevention of Alzheimer's Disease, in a subject in need of such treatment or prevention, which comprises administering to such subject a therapeutically effective amount of a compound selected from:
- furan-2-carboxylic acid [3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amide;
- 2-methyl-oxazole-4-carboxylic acid [3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amide;
- 2,5-dimethyl-oxazole-4-carboxylic acid [3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amide;
- 2-methyl-thiazole-4-carboxylic acid [3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amide;
- 4-bromo-furan-2-carboxylic acid [3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amide;
- and 5-trifluoromethyl-furan-3-carboxylic acid [3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amide;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.