US 2012/0238549 A1 · Nuclear Hormone Receptor Modulators

Abstract

The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Claims46

Dependent claims

A compound of Formula (I)

pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, isomers, and stereoisomers wherein
Ring A is optionally substituted aryl, optionally substituted saturated or partially unsaturated (C5-C6)carbocyclyl or optionally substituted heteroaryl;
Ring C is optionally substituted saturated or partially unsaturated (C5-C6)carbocyclyl or optionally substituted heterocyclyl;
Q and T are independently C or N, provided that both are not N;
Ring B is a seven membered ring wherein
X is —C(R5)2—, —C(R5)—, —C(═O)—, —N(Ra)—, —O—, —S—, —S(O)—, or —S(O)2—;
or
when X is —C(R5)2—, it can form a cyclopropyl ring spiro to the carbon atom to which it is attached;
Y is —C(R5)2C(R5)2—, —C(R5)C(R5)2—, —C(R5)2C(R5)—, —OC(R5)2—, —N(Ra)C(R5)2—, —C(R5)2N(Ra)—, —C(═O)C(R5)2—, —C(R5)2C(═O)—, —O—C(═O)—, —C(═O)—O—, or —C(R5)2—O—;
or
Y is —C(R5)2— when Q or T is N;
Z is CR4 or N;
or
Ring B is a six membered ring wherein
Y is —C(R5)2—;
Q or T must be N;
Z is CR4 or N;
or
when X is —C(R5)2—, it can form a cyclopropyl ring spiro to the carbon atom to which it is attached;
provided that X—Y or Y—Z do not form O—O, N—N, N—O, C(═O)—C(═O), N—C—O or O—C—O bonds;
and
provided that in X—Y a sulfur atom is not adjacent to an oxygen atom or —C(═O);
provided that X—Y does not form —O—C(R5)2—O—, —N—C(R5)2—O— or —S—C(R5)2—O—;
R1 is H, Br, Cl, F, —COORa, —ORa, —O-optionally substituted (C1-C3)alkylene-optionally substituted aryl, —O-optionally substituted (C1-C3)alkylene-optionally substituted heteroaryl, —O-optionally substituted (C1-C3)alkylene-optionally substituted heterocyclyl, optionally substituted (C1-C3)alkyl, optionally substituted aryl, optionally substituted (C3-C6)cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, —C(O)N(Ra)(CH2)r—Rb, —N(Ra)C(O)(CH2)r—Rb, —S(O)2N(Ra)—Rb—N(Ra)S(O)2—Rb, —O—S(O)2—CF3, —N(Ra)-optionally substituted (C3-C6)cycloalkyl, —N(Ra)-optionally substituted heterocyclyl, —N(Ra)-optionally substituted heteroaryl, —N(Ra)-optionally substituted aryl,
R2 is —(CH2)r-optionally substituted aryl, —(CH2)r-optionally substituted (C3-C6)cycloalkyl, optionally substituted (C1-C3)alkyl, or —(CH2)r-optionally substituted heteroaryl;
R3 is independently H, deuterium, —CD3, —CF3, optionally substituted (C2-C6)alkynyl, oxo, —ORa, —OP(═O)(OH)(OH), optionally substituted (C1-C4)alkyl, —(C(Ra)2)r-optionally substituted (C3-C6)cycloalkyl, —(C(Ra)2)r-optionally substituted aryl, —(C(Ra)2)r-optionally substituted heteroaryl, —(C(Ra)2)r—N(Ra)-optionally substituted heteroaryl, a carbocyclic or heterocyclic spirocyclic moiety attached to ring C;
R4 is H, optionally substituted (C1-C3)alkyl, OH or —O-optionally substituted (C1-C3)alkyl;
R5 is independently H, F, N(Ra), ORa, optionally substituted (C3-C6)cycloalkyl, or optionally substituted (C1-C3)alkyl;
Ra is independently H, optionally substituted (C3-C6)cycloalkyl or optionally substituted (C1-C3)alkyl;
Rb is H, optionally substituted (C1-C3)alkyl, optionally substituted aryl, optionally substituted (C3-C6)cycloalkyl, optionally substituted heteroaryl or optionally substituted heterocyclyl;
m is 1, 2, 3 or 4;
n is 1, 2, 3 or 4;
and
r is independently 0, 1 or 2.

31 more elements

A compound of Formula (I) wherein the compound is

(4aR,11bS)-11b-benzyl-9-hydroxy-1,2,4,4a,5,6,7,11b-octahydro-dibenzo[a,c]cyclohepten-3-one;
compound with (4aS,11bR)-11b-benzyl-9-hydroxy-1,2,4,4a,5,6,7,11b-octahydro-dibenzo[a,c]cyclohepten-3-one;
(3R,4aS,11bS)-11b-Benzyl-3-methyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cycloheptene-3,9-diol;
compound with (3S,4aR,11bR)-11b-benzyl-3-methyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cycloheptene-3,9-diol;
(3R,4aR,11bR)-11b-benzyl-3-methyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cycloheptene-3,9-diol;
compound with (3S,4aS,11bS)-11b-benzyl-3-methyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cycloheptene-3,9-diol;
(7aS,11aS)-11a-Benzyl-9-oxo-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,11aR)-11a-benzyl-9-oxo-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aS)-11a-benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9R,11aR)-11a-benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aR)-11a-benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aS)-11a-Benzyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9R,11aR)-11a-benzyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-benzyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-methoxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-benzyl-9-hydroxy-9-methoxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,11aS)-11a-Benzyl-9-hydroxy-N-(2-methylpyridin-3-yl)-6-oxo-9-(trifluoromethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[b,d]azepine-3-carboxamide;
(4aS,11bS)-11b-benzyl-3-hydroxy-N-(2-methylpyridin-3-yl)-7-oxo-3-(trifluoromethyl)-2,3,4,4 a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-5-oxo-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-benzyl-9-ethyl-9-hydroxy-5-oxo-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-5-oxo-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aR)-11a-benzyl-9-ethyl-9-hydroxy-5-oxo-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aS)-9-Ethyl-9-hydroxy-11a-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aS,9R,11aR)-9-ethyl-9-hydroxy-11a-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9R,11aS)-9-ethyl-9-hydroxy-11a-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aS,9S,11aR)-9-ethyl-9-hydroxy-11a-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(3S,4aS,11bS)-11b-Benzyl-3-prop-1-ynyl-2,3,4,4 a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cycloheptene-3,9-diol;
compound with (3R,4 aR,11bR)-11b-benzyl-3-prop-1-ynyl-2,3,4,4 a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cycloheptene-3,9-diol;
(7aS,9S,11aS)-11a-Benzyl-9-hydroxy-9-prop-1-ynyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9R,11aR)-11a-benzyl-9-hydroxy-9-prop-1-ynyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-benzyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-benzyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aS)-11a-Benzyl-9-ethynyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aS,9S,11aS)-11a-benzyl-9-ethynyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethoxymethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-benzyl-9-ethoxymethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-9-Benzyl-9-hydroxy-11a-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aS)-9-benzyl-9-hydroxy-11a-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-9-benzyl-9-hydroxy-11a-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9R,11aS)-9-benzyl-9-hydroxy-11a-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(6aS,8R,10aS)-10a-Benzyl-8-ethyl-1-methyl-1,4,5,6,6a,7,8,9,10,10a-decahydro-1,2-diaza-benzo[e]azulen-8-ol;
compound with (6aR,8S,10aR)-10a-benzyl-8-ethyl-1-methyl-1,4,5,6,6a,7,8,9,10,10a-decahydro-1,2-diaza-benzo[e]azulen-8-ol;
(6aS,8S,10aS)-10a-Benzyl-8-ethyl-1-methyl-1,4,5,6,6a,7,8,9,10,10a-decahydro-1,2-diaza-benzo[e]azulen-8-ol;
compound with (6aR,8R,10aR)-10a-benzyl-8-ethyl-1-methyl-1,4,5,6,6a,7,8,9,10,10a-decahydro-1,2-diaza-benzo[e]azulen-8-ol;
(6aS,8R,10 aS)-10a-Benzyl-8-ethyl-2-methyl-2,4,5,6,6a,7,8,9,10,10a-decahydro-1,2-diaza-benzo[e]azulen-8-ol;
compound with (6aR,8S,10aR)-10a-benzyl-8-ethyl-2-methyl-2,4,5,6,6a,7,8,9,10,10a-decahydro-1,2-diaza-benzo[e]azulen-8-ol;
(6aS,8S,10 aS)-10a-benzyl-8-ethyl-2-methyl-2,4,5,6,6a,7,8,9,10,10a-decahydro-1,2-diaza-benzo[e]azulen-8-ol;
compound with (6aR,8R,10aR)-10a-benzyl-8-ethyl-2-methyl-2,4,5,6,6a,7,8,9,10,10a-decahydro-1,2-diaza-benzo[e]azulen-8-ol;
(2R,3R,4aS,11bR)-11b-Benzyl-3-phenyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cycloheptene-2,3,9-triol compound with (2S,3S,4aR,11bS)-11b-benzyl-3-phenyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cycloheptene-2,3,9-triol;
(7aS,9R,10R,11aR)-11a-Benzyl-9,10-dihydroxy-9-phenyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,10S,11aS)-11a-benzyl-9,10-dihydroxy-9-phenyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aS)-11a-Ethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-11a-Ethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aS)-9,11a-Diethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-9,11a-Diethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9R,11aS)-11a-Ethyl-9-hydroxy-9-isobutyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-11a-Ethyl-9-hydroxy-9-isobutyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9R,11aS)-9-Cyclopropylmethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-9-Cyclopropylmethyl-11a-ethyl-9-hydroxy-6,7,7a, 8,9,10,11,11a-octahydro-5H-dibenzo[a,e]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-9-Hydroxy-9-propyl-11a-(2,2,2-trifluoro-ethyl)-6,7,7a, 8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-9-hydroxy-9-propyl-11a-(2,2,2-trifluoro-ethyl)-6,7,7a, 8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-11a-Ethyl-9-hydroxy-9-isobutyl-6,7,7a,8,9,10,11,11a-octahydro-5-oxa-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9R,11aS)-11a-Ethyl-9-hydroxy-9-isobutyl-6,7,7a,8,9,10,11,11a-octahydro-5-oxa-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-9-Cyclopropylmethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5-oxa-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9R,11aS)-9-Cyclopropylmethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5-oxa-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-11a-Ethyl-9-hydroxy-9-isobutyl-6,7,7a,8,9,10,11,11a-octahydro-5-oxa-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9R,11aS)-11a-Ethyl-9-hydroxy-9-isobutyl-6,7,7a,8,9,10,11,11a-octahydro-5-oxa-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-9-Cyclopropylmethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5-oxa-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-9-Cyclopropylmethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5-oxa-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-9-Hydroxy-9-propyl-11a-(2,2,2-trifluoro-ethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aR)-9-Hydroxy-9-propyl-11a-(2,2,2-trifluoro-ethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aS)-11a-Ethyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-11a-ethyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9R,11aS)-11a-Ethyl-9-hydroxy-5-oxo-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-11a-Ethyl-9-hydroxy-5-oxo-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aS)-9-Hydroxy-9-isobutyl-11a-(2,2,2-trifluoro-ethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9R,11aR)-9-hydroxy-9-isobutyl-11a-(2,2,2-trifluoro-ethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-9-Cyanomethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aS)-9-cyanomethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-cyanomethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-Benzyl-9-cyanomethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-cyanomethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aR)-11a-Benzyl-9-cyanomethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2,4-dimethyl-pyrimidin-5-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (3,5-dimethyl-pyrazin-2-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (3-methyl-pyridin-4-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2,6-dimethyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c a,c]cycloheptene-3-carboxylic acid (3-methyl-pyridin-2-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid [1,3,4]thiadiazol-2-ylamide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-2H-pyrazol-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2,5-dimethyl-2H-pyrazol-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2,4-dimethyl-pyrimidin-5-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (1-methyl-1H-tetrazol-5-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (5-methyl-2H-pyrazol-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-ylmethyl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-ethyl-2H-pyrazol-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid [2-methyl-6-(2H-pyrazol-3-yl)-pyridin-3-yl]-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid [2-methyl-6-(1H-pyrazol-4-yl)-pyridin-3-yl]-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid methyl-(2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-11a-Ethyl-9-hydroxy-9-(2,2,2-trifluoro-ethoxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide:
compound with (7aR,9S,11aS)-11a-ethyl-9-hydroxy-9-(2,2,2-trifluoro-ethoxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethoxymethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aR)-11a-Benzyl-9-ethoxymethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-(2,2,2-trifluoro-ethoxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR-11a-Benzyl-9-hydroxy-9-(2,2,2-trifluoro-ethoxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-(oxetan-3-ylmethoxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-Benzyl-9-hydroxy-9-(oxetan-3-ylmethoxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-isopropoxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-Benzyl-9-hydroxy-9-isopropoxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-prop oxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR-11a-Benzyl-9-hydroxy-9-prop oxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-(2,2,2-trifluoro-1-methyl-ethoxymethyl)-5,7,7a,8,9,10,11,11a-octahydro-dibenzo[c,e]oxepine-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-Benzyl-9-hydroxy-9-(2,2,2-trifluoro-1-methyl-ethoxymethyl)-5,7,7a,8,9,10,11,11a-octahydro-dibenzo[c,e]oxepine-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-prop oxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR-11a-Benzyl-9-hydroxy-9-propoxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-(tetrahydro-pyran-4-yloxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-Benzyl-9-hydroxy-9-(tetrahydro-pyran-4-yloxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-phenoxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-Benzyl-9-hydroxy-9-phenoxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-hydroxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-Benzyl-9-hydroxy-9-hydroxymethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-9-(2-methanesulfonyl-ethoxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-Benzyl-9-hydroxy-9-(2-methanesulfonyl-ethoxymethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-9-Ethoxymethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aS)-9-ethoxymethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-9-Ethoxymethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aS)-9-ethoxymethyl-11a-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(4aS,11bS)-11b-Benzyl-6-methyl-N-(2-methylpyridin-3-yl)-3-oxo-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carb oxamide;
(3S,4aS,11bS)-11b-benzyl-3-hydroxy-6-methyl-N-(2-methylpyridin-3-yl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide;
(7aS,11aS)-11a-Benzyl-N-(2-methylpyridin-3-yl)-7,9-dioxo-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5-oxo-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aR,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6-oxo-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-11a-Ethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-9-propyl-6,7,7a,8,9,10,11,11a-octahydrodibenzo[b,d]oxepine-3-carboxamide;
compound with (7aR,9S,11aS)-11a-ethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-9-propyl-6,7,7a,8,9,10,11,11a-octahydrodibenzo[b,d]oxepine-3-carboxamide;
(7aR,9S,11aS)-11a-ethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-9-propyl-6,7,7a,8,9,10,11,11a-octahydrodibenzo[b,d]oxepine-3-carboxamide;
(7aS,9R,11aR)-11a-ethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-9-propyl-6,7,7a,8,9,10,11,11a-octahydrodibenzo[b,d]oxepine-3-carboxamide;
(7aS,9R,11aR)-11a-Ethyl-9-hydroxy-9-phenyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aS)-11a-ethyl-9-hydroxy-9-phenyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,10R,11aR)-11a-Ethyl-9,10-dihydroxy-9-phenyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,10S,11aS)-11a-Ethyl-9,10-dihydroxy-9-phenyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-amino-phenyl)-amide;
(3R,4aS,11bS)-9-(1H-benzoimidazol-2-yl)-11b-benzyl-3-ethyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cyclohepten-3-ol;
(7aS,9R,11aR)-11a-Ethyl-9-hydroxy-9-propyl-7a,8,9,10,11,11a-hexahydro-7H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide compound with (7aR,9S,11aS)-11a-ethyl-9-hydroxy-9-propyl-7a,8,9,10,11,11a-hexahydro-7H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-11a-Ethyl-9-hydroxy-9-propyl-7a,8,9,10,11,11a-hexahydro-7H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aS)-11a-ethyl-9-hydroxy-9-propyl-7a,8,9,10,11,11a-hexahydro-7H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-7a,8,9,10,11,11a-hexahydro-7H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aR)-11a-Benzyl-9-ethyl-9-hydroxy-7a,8,9,10,11,11a-hexahydro-7H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-11a-Ethyl-9-hydroxy-9-(3,3,3-trifluoro-propyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9R,11aS)-11a-ethyl-9-hydroxy-9-(3,3,3-trifluoro-propyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-11a-Ethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-9-phenyl-6,7,7a,8,9,10,11,11a-octahydrodibenzo[b,d]oxepine-3-carboxamide;
compound with (7aR,9S,11aS)-11a-ethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-9-phenyl-6,7,7a,8,9,10,11,11a-octahydrodibenzo[b,d]oxepine-3-carboxamide;
(7aS,9R,10R,11aR)-11a-Ethyl-9,10-dihydroxy-N-(2-methylpyridin-3-yl)-9-phenyl-6,7,7a,8,9,10,11,11a-octahydrodibenzo[b,d]oxepine-3-carboxamide;
compound with (7aR,9S,10S,11aS)-11a-ethyl-9,10-dihydroxy-N-(2-methylpyridin-3-yl)-9-phenyl-6,7,7a,8,9,10,11,11a-octahydrodibenzo[b,d]oxepine-3-carboxamide;
(7aS,9R,11aR)-11a-Ethyl-9-propyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
compound with (7aR,9S,11aS)-11a-ethyl-9-propyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aR,9S,11aS)-11a-ethyl-9-propyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aS,9R,11aR)-11a-Ethyl-9-propyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aS,9S,11aR)-11a-Ethyl-9-hydroxy-9-isobutyl-5,7,7a,8,9,10,11,11a-octahydro-dibenzo[c,e]oxepine-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-9,11a-diethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aR,9S,11aS)-9,11a-diethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aR,9S,11aS)-9,11a-diethyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (4-amino-phenyl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (3-amino-phenyl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-benzo[c]pyrrolo[1,2-a]azepine-2-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-benzo[c]pyrrolo[1,2-a]azepine-2-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-amino-phenyl)-amide;
compound with (7aR,9S,11aR)-11a-benzyl-9-ethyl-9-hydroxy-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-amino-phenyl)-amide;
(3R,4aS,11bS)-9-(1H-Benzoimidazol-2-yl)-11b-benzyl-3-ethyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cyclohepten-3-ol;
compound with (3S,4aR,11bR)-9-(1H-benzoimidazol-2-yl)-11b-benzyl-3-ethyl-2,3,4,4 a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cyclohepten-3-ol;
(3R,4aS,11bS)-9-(1H-Benzoimidazol-2-yl)-11b-benzyl-3-ethyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cyclohepten-3-ol;
(3S,4aR,11bR)-9-(1H-benzoimidazol-2-yl)-11b-benzyl-3-ethyl-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[a,c]cyclohepten-3-ol;
(7aS,9R,11aR)-11a-Ethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-amino-pyridin-3-yl)-amide;
compound with (7aR,9S,11aS)-11a-Ethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-amino-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Cyclopropylmethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aR,9S,11aR)-11a-cyclopropylmethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
or
(7aS,9R,11aR)-11a-Ethyl-9-hydroxy-9-propyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-chloro-phenyl)-amide.

184 more elements

A compound of Formula (I) wherein the compound is

(4aS,11bS)-11b-Benzyl-9-hydroxy-1,2,4,4 a,5,6,7,11b-octahydro-dibenzo[a,c]cyclohepten-3-one;
compound with (4aR,11bR)-11b-benzyl-9-hydroxy-1,2,4,4a,5,6,7,11b-octahydro-dibenzo[a,c]cyclohepten-3-one;
(7aR,11aS)-11a-Benzyl-9-oxo-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aS,11aR)-11a-benzyl-9-oxo-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9R,11aS)-11a-Benzyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aS,9S,11aR)-11a-benzyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9S,11aS)-11a-benzyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
compound with (7aS,9R,11aR)-11a-benzyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aS)-11a-Benzyl-9-hydroxy-N-(2-methylpyridin-3-yl)-6-oxo-9-(trifluoromethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[b,c1]azepine-3-carboxamide;
(7aR,9R,11aS)-11a-Benzyl-9-hydroxy-9-trifluoromethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-2H-pyrazol-3-yl)-amide;
(7aR,9R,11aS)-11a-Benzyl-9-hydroxy-9-trifluoromethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (3-methyl-pyridin-4-yl)-amide;
(7aS,9S,11aR)-11a-Benzyl-9-hydroxy-9-trifluoromethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-2H-pyrazol-3-yl)-amide;
(7aS,9R,11aS)-11a-benzyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9R,11aR)-11a-benzyl-9-hydroxy-9-methyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aR,9R,11aS)-11a-Benzyl-9-hydroxy-9-trifluoromethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(7aS,9S,11aR)-11a-Benzyl-9-hydroxy-9-trifluoromethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide;
(3R,4aR,11bS)-11b-Benzyl-3-ethyl-3-hydroxy-6-methyl-N-(2-methylpyridin-3-yl)-7-oxo-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide;
(7aR,9R,11aS)-11a-Benzyl-9-hydroxy-N-(2-methylpyridin-3-yl)-5-oxo-9-(trifluoromethyl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(7aR,9R,11aS)-11a-Benzyl-9-hydroxy-N-(2-methylpyridin-3-yl)-9-(trifluoromethyl)-5,7,7a,8,9,10,11,11a-octahydrodibenzo[c,e]oxepine-3-carboxamide;
(3R,4aR,11bS)-11b-Benzyl-3-hydroxy-6-methyl-N-(2-methylpyridin-3-yl)-3-(trifluoromethyl)-2,3,4,4a,5,6,7,11b-octahydro-1H-dibenzo[c,e]azepine-9-carboxamide;
or
(7aR,9R,11aS)-11a-Benzyl-9-hydroxy-5-oxo-9-trifluoromethyl-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide.

19 more elements

A method of treating a disease or condition comprising administering a therapeutically effective amount of a compound of Formula (I).

Dependencies are inferred from the claim text.

Nuclear Hormone Receptor Modulators

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Nuclear Hormone Receptor Modulators

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Abstract

Claims46