Macrocyclic amides, pharmaceutical compositions, preparation methods and uses thereof
AssigneeYuxi Winhey Bio-Tech Co., Ltd.
InventorsChongren Yang, Haizhou Li, Ping Zhao, Yingjun Zhang
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Abstract
Macrocyclic amide WH-21091 with antibacterial and antitumor activities, its analogs, preparation methods and uses thereof. The said macrocyclic amides are prepared by microbes of Xenorhabdus and Photorhabdus, or they can be prepared by other living beings through transgenic techniques. The compositions of the said macrocyclic amide and its analogs can be used as drugs and/or agricultural chemicals for treatment of microbial infections, especially for treatment of infectious diseases of Staphylococcus aureus with drug resistance. The said compositions can also be used as drugs for treatment of cancers of human beings or animals.
Claims19
A macrocyclic amide, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, wherein the macrocyclic amide has the structure of formula II:
- wherein, R1-R15 each independently represents hydrogen atom, alkyl, cycloalkyl, alkenyl, alkynyl, aromatic group or a group containing one or more of oxygen, nitrogen, sulfur or halogen atoms, wherein the group containing oxygen includes hydroxyl, acyl, ketone group, and carboxyl, and the group contain nitrogen includes amino and nitro.
8-11. (canceled)
(canceled)
Dependencies are inferred from the claim text.