Isoxazolidine derivatives

A compound of formula (I):

• wherein
• R1 is (CH2)n—Z—(CH2)n′—R4
• n is 0, 1 or 2;
• n′ is 0, 1 or 2;
• Z is a single bond or is selected from the group consisting of —S—, —O—, —C(O)—, and —NR3;
• R3 is selected from the group consisting of H, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C8)cycloalkyl, aryl, aryl(C1-C6)alkyl, and heteroaryl, which are optionally substituted by —CN;
• R4 is selected from the group consisting of:
• H, halogen, —OH, —SH, —CN, and —NR6R7;
• aryl(C1-C6)alkyl, (C1-C6)alkylsulfonyl, (C1-C6)alkylcarbonyl, (C1-C6)alkylcarboxyl, HO(C1-C6)alkylcarboxyl, (C1-C6)alkylamide, and (C1-C6)alkoxy, which are optionally substituted by one or more oxo groups;
• (C1-C6)alkyl which may be optionally substituted by one or more substituents selected from the group consisting of a halogen atom, —CN, —OH, —NH2, —NO2, —CF3, and —SH;
• (C2-C6)alkynyl;
• (C5-C17)alkenylcarbonyl;
• and
• a mono-, bi-, or tricyclic saturated or partially unsaturated or unsaturated ring, optionally substituted by one or more halogen atoms or oxo groups;
• R6 and R7 are independently selected from the group consisting of H, (C1-C6)alkyl, and (C1-C6)alkoxy;
• X and Y are independently H or halogen atoms;
• R2 is selected from the group consisting of:
• —(CH2)s—K-A-(CH2)t—W, —(CH2)s—K—(CH2)t—B—W, and —(CH2)s—(CHR5)—W;
• s is 0 or 1;
• t is 0 or 1;
• K is selected from the group consisting of a group —CH═CH—, arylene, and heteroarylene, where such arylene and heteroarylene groups may be optionally substituted by one or more groups independently selected from:
• halogen, (C1-C6)alkyl, —OH, (C1-C6)alkoxy, and (C1-C6)haloalkyl;
• A is selected from the group consisting of a bond, —O—, and —S—;
• B is selected from the group consisting of a bond, —O—, and —S—;
• W is aryl or heteroaryl, where such aryl and heteroaryl groups may be optionally substituted by one or more groups independently selected from:
• halogen, —OH, (C1-C6)alkyl, (C1-C6)alkoxy, and (C1-C6)haloalkyl;
• R5 is aryl or heteroaryl, where such aryl and heteroaryl groups may be optionally substituted by one or more groups independently selected from halogen, (C1-C6)alkyl, (C1-C6)alkoxy, —OH, and (C1-C6)haloalkyl;
• or a pharmaceutically acceptable salt thereof;
• with the proviso that when s is 1, K is optionally substituted heteroarylene, t is zero, and A or B is a bond, then W is optionally substituted heteroaryl.