Fatty acid acetylated salicylates and their uses
AssigneeCatabasis Pharmaceuticals, Inc.
InventorsJill C. MILNE, Michael R. Jirousek, Jean E. Bemis, Jesse J. Smith
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Abstract
The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.
Claims16
A method of treating inflammation, comprising administering to a patient in need thereof an effective amount of a compound of Formula III:
- or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof,
- wherein
- each W1 and W2 are independently null, O, or NH, or when W1 and W2 are both NH, then both W1 and W2 can be taken together to form a piperazine moiety;
- - - - - - represents an optional bond that when present requires that Q is null;
- each a and c are independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
- each b is H, CH3, C(O)OH, or O—Z;
- each d is H or C(O)OH;
- each n, o, p, and q is independently 0 or 1;
- each Z is H or
- with the proviso that there is at least one
- in the compound;
- each r is independently 2, 3, or 7;
- each s is independently 3, 5, or 6;
- each t is independently 0 or 1;
- u is 0 or 1;
- with the proviso that when r is 7, s is 3;
- Q is null, C(O)CH3, Z,
- e is H or any one of the side chains of the naturally occurring amino acids;
- W3 is null, —O—, or —N(R)—;
- R is H or C1-C3 alkyl;
- and
- T is H, C(O)CH3, or Z.
A method of treating inflammation, comprising administering to a patient in need thereof an effective amount of a compound of Formula IIIa,
- or pharmaceutically acceptable salts, enantiomers, and stereoisomers thereof,
- wherein
- each W1 and W2 are independently null, O, or NH, or when W1 and W2 are both NH, then both W1 and W2 can be taken together to form a piperazine moiety;
- - - - - - represents an optional bond that when present requires that Q is null;
- each a and c are independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
- each b is H, CH3, C(O)OH, or O—Z;
- each d is H or C(O)OH;
- each n, o, p, and q is independently 0 or 1;
- each Z is H or
- with the proviso that there is at least one
- in the compound;
- each r is independently 2, 3, or 7;
- each s is independently 3, 5, or 6;
- each t is independently 0 or 1;
- u is 0 or 1;
- with the proviso that when r is 7, s is 3;
- each Q is null, H, C(O)CH3, Z,
- each e is H or any one of the side chains of the naturally occurring amino acids;
- W3 is null, —O—, or —N(R)—;
- R is H or C1-C3 alkyl;
- and
- T is H, C(O)CH3, or Z.
Dependencies are inferred from the claim text.