Compositions and Methods for the Treatment of Musculoskeletal Related Diseases and Disorders Using Metal Ion-Citrate Analog Complexes

A pharmaceutical composition for the treatment of musculoskeletal related injuries, diseases or disorders, the composition comprising a citrate analog compound or a pharmaceutically acceptable salt thereof, the citrate analog compound being selected from the group consisting of:

A pharmaceutical composition for the treatment of musculoskeletal related injuries, diseases or disorders, the composition comprising a citrate analog compound or a pharmaceutically acceptable salt thereof, the citrate analog compound being selected from the group consisting of:

A method for treating a musculoskeletal diseases or disorder comprising the step of administering to a subject an effective amount a compound composition comprising a citrate analog compound or a pharmaceutically acceptable salt thereof that is complexed with a metal ion.

A method for treating a musculoskeletal diseases or disorder comprising the step of administering to a subject an effective amount a compound composition comprising a citrate analog compound or a pharmaceutically acceptable salt thereof that is complexed with a metal ion and wherein the citrate analog comprises a compound having the following base formula (I):

• where X may be one of the following:
• wherein Y, Y′, and Y″ are independently a citrate moiety, O, O—Y, OH, NH, NH—Y, R and R—Y, with R being an alkyl, alkene, ester, aryl, or phenyl group having from 1 to 6 carbon atoms.