Granulated anthelmintic preparations and delivery systems
AssigneeArgenta Innovation Limited
InventorsDouglas Robert Cleverly, Debashis Mukhopadhyay
Life of this patent
Estimating the term…
Abstract
The present invention relates to anthelmintic compositions comprising two or more anthelmintic active agents selected from one or more of the following groups; imidazothiazoles such as levamisole, benzimidazoles such as oxfendazole, or fenbendazole, macrocylic lactones such as ivermectin or avermectin, salicylanilides, and praziquantel. The composition being in the form of stable granules that are readily dispersible in water so as to provide a homogenous mixture of the anthelmintic agents suitable for administration. Methods of preparing the composition are also described.
Claims20
An anthelmintic composition in the form of a stable granule(s) comprising two or more anthelmintic actives selected from one or more imidazothiazoles, one or more benzimidazoles, one or more macrocyclic lactones, one or more salicylanilides, praziquantel, the stable granule being readily dispersible in water to provide a homogenous mixture of the anthelmintic actives for administration to a non-human mammal,
- the granule further comprising a suspending agent if the anthelmintic actives comprise a benzimidazole, a wetting agent if the anthelmintic actives comprise a macrocyclic lactone, a wetting agent if the anthelmintic actives comprise a salicylanilide and a suspending agent if the anthelmintic actives comprise praziquantel.
A dosage system for orally dosing animals with an anthelmintic agent, the system comprising
- (a) one or more packs of granules for addition into an aqueous liquid, the granules comprising
- (i) a benzimidazole and a suspending agent for the benzimidazole,
- (ii) a macrocylic lactone and a wetting agent,
- (iii) a salicylanilide and a wetting agent,
- (iv) praziquantel and a wetting agent,
- (v) an imidazothiazole and one or more anthelmintic agents selected from benzimidazoles, macrocylic lactones, salicylanilides, and praziquantel, and optionally a suspending agent,
- (b) a suspending agent if (i) the granules do not comprise a suspending agent, or (ii) additional suspending agent is required to suspend the anthelmintic actives in the liquid.
A method of preparing a stable liquid delivery formulation for treating an animal comprising the steps of
- (a) providing one or more packs of granules, the granules comprising
- (i) a benzimidazole and a suspending agent for the benzimidazole,
- (ii) a macrocylic lactone and a wetting agent,
- (iii) a salicylanilide and a wetting agent,
- (iv) praziquantel and a wetting agent,
- (v) an imidazothiazole and one or more anthelmintic agents selected from benzimidazoles, macrocylic lactones, salicylanilides, and praziquantel, and optionally a suspending agent,
- (b) adding the granules from the one or more packs of granules to an aqueous liquid,
- (c) adding a suspending agent if (i) the granules do not comprise a suspending agent, or (ii) additional suspending agent is required to suspend the anthelmintic actives in the liquid.
A method of forming an anthelmintic composition comprising the steps of:
- providing two or more anthelmintic actives selected from one or more imidazothiazoles, one or more benzimidazoles, one or more macrocyclic lactones, and praziquantel, providing a suspending agent if the anthelmintic actives comprise a macrocyclic lactone,
- providing a wetting agent if the anthelmintic actives comprises a benzimidazole, mixing the macrocylic lactone with the suspending agent if a macrocylic lactone is present,
- mixing the benzimidazole with the wetting agent if a benzimidazole is present, combining the anthelmintic actives, and
- granulating the anthelmintic actives.
Dependencies are inferred from the claim text.