Methods for Promoting Wound Healing and/or Reducing Scar Formation
AssigneeArizona Board of Regents
InventorsColleen BROPHY, Alyssa Panitch, Catherine Parmiter, Elizabeth Furnish, Padmini Komalavilas
Life of this patent
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Abstract
The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.
Claims23
A method for reducing scar formation, comprising administering to an individual in need thereof an amount effective to reduce scar formation of a polypeptide comprising a sequence according general formula I:
- X1-A(X2)APLP-X3
- wherein X1 is 0-14 amino acids of the sequence of heat shock protein 20 between residues 1 and 14 of SEQ ID NO:
- 298;
- X2 is selected from the group consisting of S, T, Y, D, E, hydroxylysine, hydroxyproline, phosphoserine analogs and phosphotyrosine analogs;
- and
- X3 is selected from the group consisting of (a) 0-140 amino acids of heat shock protein between residues 21 and 160 of SEQ ID NO:
- 298;
- and (b) 0, 1, 2, or 3 amino acids of a sequence of genus Z1-Z2-Z3, wherein Z1 is selected from the group consisting of G and D;
- Z2 is selected from the group consisting of L and K;
- and
- Z3 is selected from the group consisting of S, T, and K.
(canceled)
(canceled)
A method for promoting wound healing, comprising administering to an individual in need thereof an amount effective to promote wound healing of a polypeptide comprising a sequence according general formula I:
- X1-A(X2)APLP-X3 wherein X1 is 0-14 amino acids of the sequence of heat shock protein 20 between residues 1 and 14 of SEQ ID NO:
- 298;
- X2 is selected from the group consisting of S, T, Y, D, E, hydroxylysine, hydroxyproline, phosphoserine analogs and phosphotyrosine analogs;
- and
- X3 is selected from the group consisting of (a) 0-140 amino acids of heat shock protein 20 between residues 21 and 160 of SEQ ID NO:
- 298;
- and (b) 0, 1, 2, or 3 amino acids of a sequence of genus Z1-Z2-Z3, wherein Z1 is selected from the group consisting of G and D;
- Z2 is selected from the group consisting of L and K;
- and
- Z3 is selected from the group consisting of S, T, and K.
(canceled)
Dependencies are inferred from the claim text.