Alpha helical mimics, their uses and methods for their production

A compound having the formula (I):

• wherein the Xaa are L-alpha amino acid residues, 2 or 3 of which are favorable to alpha helix formation;
• or
• wherein the Xaa are D-alpha amino acid residues, 2 or 3 of which are favorable to alpha helix formation;
• wherein the amino acid residues that are favorable to alpha helix formation are selected from alanine, arginine, lysine, methionine, leucine, glutamic acid, glutamine, cysteine, isoleucine, phenylalanine, tryptophan, histidine and aspartic acid;
• wherein the compound has at least three (1,5) intramolecular hydrogen bonds;
• R1 is selected from an N-terminal capping group, a non-peptidic group or a group that mimics an amino acid side chain, an amino acid residue optionally capped by an N-terminal capping group, a non-peptidic group or a group that mimics an amino acid side chain;
• R2 is selected from a C-terminal capping group, a group that mimics an amino acid side chain or a group that activates the terminal carboxylic acid carbonyl group to nucleophilic substitution, an amino acid residue optionally capped by a C-terminal capping group, a group that mimics an amino acid side chain or a group that activates the terminal carboxylic acid carbonyl group to nucleophilic substitution;
• each R9 and R0 are independently selected from H, C1-C10alkyl, C2-C1-C10alkenyl, C2-C10alkynyl, C3-C10cylcoalkyl, C5-C10cycloalkenyl, —OH, —OC1-C10alkyl, —NH2, —NH(C1-C10alkyl), —N(C1-C10alkyl)2, C6-C12 zaryl, C3-C10heterocyclyl, C5-C10heteroaryl and halo;
• L is selected from —NH—C(O)—, —C(O)—NH—, —S—S—, —CH(OH)CH2—, CH2CH(OH)—, —CH═CH—, —CH2—CH2—, —NH—CH2— —CH2—NH—, —CH2—S—, —S—CH2—, —C(O)—CH2—, —CH2—C(O)—, —S(O)t—NH-—NH—S(O)t—, CH2—P(═O)(OH)— and —P(═O)(OH)—CH2—;
• mis 4,
• n is 1, and
• t is 0, 1 or 2.