Loading patent…
AssigneeSnu R&Db Foundation
InventorByung-Moo MIN
Estimating the term…
The present invention relates to human laminin α2 chain LG3 domain and active peptides promoting cell adhesion, spreading, migration, and neurite outgrowth. More particularly, it was found that when nerve cells are incubated using human laminin α2 chain LG3 domain and active peptides in the LG3 domain, cell adhesion, spreading, migration, and neurite outgrowth of nerve cells promote and the promotion of cell adhesion, spreading, migration, and neurite outgrowth of nerve cells are integrin-mediated and achieved by the activation of PKCδ and FAK phosphorylation. Thus, the present invention can be very useful for researches on cell adhesion, spreading, migration, and neurite outgrowth activities of cells which are focused on nerve cells and mediated by various extracellular matrix proteins including laminin, manufacture of artificial nerve conduits, burns treatment, wounds treatment, and tissue regeneration.
A method of promoting cell adhesion, spreading, migration, growth, or regeneration in an individual, the method comprising administering a polypeptide or peptide to the individual, the polypeptide comprising human laminin-2 α2 chain large globular (LG) 3 domain sequence, the peptide being an active peptide included in the human laminin-2 α2 chain large globular (LG) 3 domain sequence and consisting of one amino acid sequence selected from the group consisting of SEQ ID NOs:
An artificial nerve conduit or scaffolds thereof comprising a polypeptide or peptide, the polypeptide comprising human laminin-2 α2 chain large globular (LG) 3 domain sequence, the peptide being an active peptide included in the human laminin-2 α2 chain large globular (LG) 3 domain sequence and consisting of one amino acid sequence selected from the group consisting of SEQ ID NOs:1 and 35 to 50.
A scaffold for tissue engineering, the scaffold comprising a polypeptide or peptide, the polypeptide comprising human laminin-2 α2 chain large globular (LG) 3 domain sequence, the peptide being an active peptide included in the human laminin-2 α2 chain large globular (LG) 3 domain sequence and consisting of one amino acid sequence selected from the group consisting of SEQ ID NOs:1 and 35 to 50.
Dependencies are inferred from the claim text.