Modulation Of Osteoclast Differentiation
AssigneeNitzozot Ltd.
InventorsZvi Bar-Shavit, Refael Aharon
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Abstract
The present invention concerns the use of an aquaprin-9 (AQP-9) modulator for the preparation of a pharmaceutical composition for treating or preventing a pathological condition associates with unbalanced osteoclast differentiation. In accordance with one embodiment, the modulator is an AQP-9 inhibitor. An example of an inhibitor is phloretin which was shown to inhibit osteoclast differentiation following induction of bone marrow cells with RANKL. The invention also concerns methods for modulating osteoclast differentiation, methods for treating pathological conditions associated with unbalanced osteoclast differentiation as well as pharmaceutical composition comprising such modulators.
Claims24
1-46. (canceled)
A method of modulating unbalanced osteoclast differentiation, the method comprising providing osteoclasts, osteoclast precursor cells or a mixture of same with an amount of an AQP-9 modulator, the amount of said modulator being effective to affect AQP-9 activity in said osteoclast cells or said precursor cells.
A method for treating or preventing in a subject a pathological condition associates with unbalanced osteoclasts differentiation, the method comprises providing said subject with an amount an AQP-9 modulator, the amount of said AQP-9 modulator being effective to affect AQP-9 activity in said unbalanced osteoclasts.
A pharmaceutical composition comprising as an active ingredient an amount of AQP-9 modulator, the amount of said AQP-9 modulator being effective to affect AQP-9 activity in osteoclast cells or osteoclast precursor cells.
Dependencies are inferred from the claim text.