Methods of modulating apoptosis by administration of relaxin agonists or antagonists
AssigneeMolecular Medicine Research Institute
InventorsEdward P. Amento, Chrishan S. Samuel
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Abstract
The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.
Claims28
A method of modulating apoptosis, comprising:
- administering to a subject in need thereof an effective amount of a relaxin agonist for a period of time sufficient to decrease apoptosis in cells expressing a relaxin receptor.
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A method for stimulating maturation, development or differentiation of an immature tissue, comprising administering to a subject in need thereof an effective amount of a relaxin agonist for a time period sufficient to stimulate tissue maturation.
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Dependencies are inferred from the claim text.