Novel Cellular Factor-Containing Solution Compositions
AssigneeStemnion, Inc.
InventorsVivienne S. Marshall, Charlotte A. Smith, Catherine J. Trumpower
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Abstract
The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.
Claims5
-24. (canceled)
1. A method for healing an ulcer on the skin or a mucous membrane comprising administering to the ulcer on the skin or a mucous membrane between 0.1-to-1000 micrograms per square centimeter of applied area an extraembryonic cell-derived cellular cytokine solution composition comprising physiologic concentrations of VEGF, TGFβ2, Angiogenin, PDGF, TIMP-1 and TIMP-2, wherein the physiologic concentration is ˜5.0-16 ng/mL for VEGF, ˜3.5-4.5 ng/mL for Angiogenin, ˜100-165 pg/mL for PDGF, ˜2.5-2.7 ng/mL for TGFβ2, ˜0.68 μg mL for TIMP-1 and ˜1.04 μg/mL for TIMP-2.
A method for healing an ulcer on the skin or a mucous membrane comprising administering to the ulcer on the skin or a mucous membrane between 0.1-to-1000 micrograms per square centimeter of applied area a physiologic cytokine solution composition comprising a therapeutic component consisting of physiologic concentrations of:
- a) VEGF, TGFβ2, Angiogenin, PDGF, TIMP-1 and TIMP-2;
- and
- b) a carrier, wherein the physiologic concentration is ˜5.0-16 ng/mL for VEGF, ˜3.5-4.5 ng/mL for Angiogenin, ˜100-165 pg/mL for PDGF, ˜2.5-2.7 ng/mL for TGFβ2, ˜0.68 μg mL for TIMP-1 and ˜1.04 μg/mL for TIMP-2, and wherein the carrier is normal saline, PBS, lactated Ringer's solution or cell culture medium.
Dependencies are inferred from the claim text.