Methods for reducing gnrh-positive tumor cell proliferation

A method for decreasing cellular replication of GnRH-receptor positive tumor cells in a subject comprising:

• (a) positively detecting and/or determining the presence of GnRH receptors and/or GnRH receptor concentration in a sample of the tumor cells derived from the subject;
• and
• (b) administering to said subject a replication-decreasing amount of a therapeutic compound comprising a GnRH analogue that is selected from Table 1 and a pharmacologically acceptable salt of any thereof, wherein said GnRH analogue interacts with the GnRH receptor to thereby cause a decrease in tumor cell replication.

A method of treating a tumor in a subject by decreasing cellular replication of malignant cells associated with said tumor comprising:

• administering to the subject a replication-decreasing amount of a GnRH agonist selected from the group consisting of leuprorelin, triptorelin, buserelin, goserelin, nafarelin, and a pharmacologically acceptable salt of any thereof, wherein the tumor is selected from the group consisting of lung oat-cell carcinoma, neurally-derived oat-cell carcinoma, Kaposi sarcoma, malignant glioma, and malignant melanoma.