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US 2012/0238465 A1Published application
Drug screening target for alzheimer's disease and method of screening potential drugs
OwnerJoseph Audie, Sergei Yaroslavovitch Ponomarevinventors
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Abstract
Drug screening targets and method of screening for potential drugs for treatment or amelioration of Alzheimer's Disease are provided.
Claims20
A polypeptide having about 30% homology to residues 38-123 of the N-terminal APP fragment (NAPP) as identified in SEQ ID NO:
- 1, said polypeptide containing 7 beta strands and wherein residues 66-81 comprise an alpha-helix-loop motif, and wherein residue 62 is Cysteine, residue 71 is Glutamine, residue 74 is Glutamine, residue 82 is Isoleucine, residue 103 is Lysine, and residue 123 is Valine.
A polypeptide having about 30% homology to residues 96-167 of death cell receptor six (DR6) as identified in SEQ ID NO:
- 2, and where said polypeptide includes a first Cysteine Rich Domains (CRD) with at least about 30% homology to amino acid residues 96 to 131 of DR6 as identified in SEQ ID NO:
- 2, and a second CRD with at least about 30% homology to amino acid residues 133 to 167 of DR6 as identified in SEQ ID NO:
- 2 and wherein residue 98 is Arginine, residue 104 is Glutamic acid, residue 131 is Cysteine, residue 132 is Threonine, residue 139 is Glutamine, residue 163 is Threonine, and residue 167 is Arginine.
Dependencies are inferred from the claim text.