Means and Methods for Diagnosing Multiple Sclerosis

A method for determining whether a multiple sclerosis therapy is successful comprising the steps of:

• a) determining at least one biomarker selected from the group consisting of the biomarkers listed in Table 1, 2, 3 and/or 4 in a first and a second sample of the subject, wherein said first sample has been taken prior to or at the onset of a multiple sclerosis therapy, and said second sample has been taken after the onset of said therapy;
• and
• b) comparing the amount of said at least one biomarker in the first sample to the amount in the second sample, whereby a change in the amount determined in the second sample in comparison to the first sample is indicative for multiple sclerosis therapy being successful.

A method for diagnosing an active status of multiple sclerosis in a subject comprising the steps of:

• a) determining in a sample of a subject an amount of at least one biomarker selected from the group consisting of the biomarkers listed in Table 3 and/or Table 4;
• and
• b) comparing the amount of said at least one biomarker to a reference amount, whereby multiple sclerosis is to be diagnosed.

A method for predicting whether a subject is at risk of developing multiple sclerosis comprising the steps of:

• a) determining in a sample of a subject an amount of at least one biomarker selected from the group consisting of the biomarkers listed in Table 1 and/or 2;
• and
• b) comparing the amount of said at least one biomarker to a reference amount, whereby it is predicted whether said subject is at risk of developing multiple sclerosis.

A method for predicting whether a subject is at risk of developing an active status of multiple sclerosis comprising the steps of:

• a) determining in a sample of a subject an amount of at least one biomarker selected from the group consisting of the biomarkers listed in Table 3 and/or 4;
• and
• b) comparing the amount of said at least one biomarker to a reference amount, whereby it is predicted whether said subject is at risk of developing an active status of multiple sclerosis.