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US 2012/0238017 A1Published application
Novel sirna structure for minimizing off-target effects and relaxing saturation of rnai machinery and the use thereof
OwnerDong Ki Lee, Chan Il Changinventors
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Abstract
The present invention relates to a novel siRNA structure and the use thereof. More particularly, the invention relates to a double-stranded small interfering RNA molecule (siRNA molecule) comprising a 19-21 nucleotide (nt) antisense strand and a 15-19 nt sense strand having a sequence complementary to the antisense sequence, wherein the 5′ end of the antisense strand has a blunt end and the 3′ end of the antisense strand has an overhang, and to a method for silencing the expression of a target gene using the siRNA molecule.
Claims6
A small interfering RNA molecule (siRNA molecule) comprising:
- a 19-21 nucleotide (nt) antisense strand;
- and a 15-17 nt sense strand having a sequence complementary to the antisense strand, wherein the 5′ end of the antisense strand has a blunt end and the 3′ end of the antisense strand has an overhang.
Dependencies are inferred from the claim text.