Cytotoxic t lymphocyte
AssigneesMie University, Takara Bio Inc.
InventorsHiroshi SHIKU, Atsunori Hiasa, Satoshi Okumura, Hiroaki Naota, Yoshihiro Miyahara
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Abstract
The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte.
Claims12
An RNA-introduced T lymphocyte into which an RNA encoding an antigen of interest is introduced, which has an activity to induce a T lymphocyte which recognizes the antigen.
A method for inducing a T lymphocyte, comprising using, as an antigen-presenting cell, an RNA-introduced T lymphocyte into which an RNA encoding an antigen of interest is introduced, to induce a T lymphocyte which recognizes the antigen.
A cytotoxic T lymphocyte which recognizes a cell presenting on the surface thereof a complex of a human major histo-compatibility antigen (HLA)-A24-restricted antigen peptide represented by SEQ ID NO:
- 1 and an HLA-A24 molecule or a complex of a functional derivative of the HLA-A24-restricted antigen peptide and an HLA-A24 molecule, and which is CD8-positive.
Dependencies are inferred from the claim text.