Mammalian-type glycosylation in plants
AssigneeStichting Dienst Landbouwkundig Onderzoek
InventorsHendrikus Antonius Cornelis Bakker, Hendrik Jan Bosch
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Abstract
The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising a functional mammalian enzyme providing N-glycan biosynthesis that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.
Claims18
1-21. (canceled)
A transgenic plant or plant cell, comprising a first exogenous gene encoding a mammalian β1,4-galactosyltransferase and a second exogenous gene encoding a mammalian sialyl transferase, wherein the transgenic plant produces a complex N-linked glycan, in which a galactose residue is attached to a N-acetylglucosamine residue and a sialic acid residue is attached to the galactose residue.
Dependencies are inferred from the claim text.