Mcam as a biomarker for fluid homeostasis
AssigneePronota N.V.
InventorKoen Kas
Life of this patent
Estimating the term…
Abstract
The application discloses MCAM as a new biomarker for fluid homeostatic imbalance; methods for predicting, diagnosing, prognosticating and/or monitoring fluid homeostatic imbalance based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods.
Claims26
A method for diagnosing, predicting, prognosticating and/or monitoring an impaired fluid homeostasis in a subject, wherein the examination phase of the method comprises measuring the quantity of melanoma cell adhesion molecule (MCAM) in a sample from the subject.
A method to determine whether a subject is or is not (such as, for example, still is, or is no longer) in need of a therapy to treat impaired fluid homeostasis, comprising:
- (i) measuring the quantity of MCAM in the sample from the subject;
- (ii) comparing the quantity of MCAM measured in (i) with a reference value of the quantity of MCAM, said reference value representing a known diagnosis, prediction and/or prognosis of impaired or normal fluid homeostasis;
- (iii) finding a deviation or no deviation of the quantity of MCAM measured in (i) from said reference value;
- (iv) inferring from said finding the presence or absence of a need for a therapy to treat impaired fluid homeostasis.
A method for diagnosing, predicting, prognosticating and/or monitoring (i) dyspnea associated with or caused by volume overload in a subject or (ii) heart failure (HF) or acute heart failure (AHF) associated with or caused by volume overload in a subject, or (iii) HF or AHF associated with or caused by systolic dysfunction in a subject, wherein the examination phase of the method comprises measuring the quantity of MCAM in a sample from the subject.
A testing device capable of measuring the quantity of MCAM in a sample from a subject comprising:
- (i) means for measuring the quantity of MCAM in said sample, and
- (ii) means of storing the reference value in the device, and
- (iii) means of comparing the obtained quantity with the stored reference value, and
- (iv) means for visualising the quantity of MCAM measured in the sample.
Dependencies are inferred from the claim text.