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US 2012/0237953 A1Published application
Methods to Identify Modulators
AssigneeGivaudan SA
InventorsNICOLE ERNA IRENE BRUNE, JAY PATRICK SLACK, IOANA MARIA UNGUREANU, KIMBERLY GRAY, CHRISTOPHER TODD SIMONS, JENNY ELLEN EVANS PENNIMPEDE
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Abstract
Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose, and an inhibitor, are provided.
Claims14
A method to identify an agent that modulates the taste of sucralose comprising:
- (i) contacting cells that express a TAS2R bitter taste receptor that is able to be activated by sucralose with sucralose in the presence of at least one agent;
- and
- (ii) determining whether the at least one agent affects binding to sucralose or a functional response thereto of said TAS2R bitter taste receptor,
- with the proviso that the cells are not unmanipulated cells in their natural environment and, wherein said TAS2R bitter taste receptor is selected from the group consisting of TAS2R1, TAS2R10, TAS2R44, and TAS2R4.
1 more element
Dependencies are inferred from the claim text.