Myosin-iia s1943 phosphorylation as a marker of tumor invasion
AssigneeAlbert Einstein College of Medicine of Yeshiva University
InventorAnne Reba Bresnick
Life of this patent
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Abstract
Methods and kits are provided for determining if cells of a tumor in an organ or a tissue in a subject are likely to invade another organ or tissue in the subject and for determining if a cancer in a subject is likely to metastasize.
Claims18
A method for determining if cells of a tumor in an organ, or of a tissue in a subject, are likely to invade another organ or tissue in the subject comprising determining if a sample of the tumor, or a sample derived from the tumor, comprises a phosphorylated S1943 residue of a myosin-IIA heavy chain, wherein cells of the tumor are likely to invade another organ or tissue if the sample comprises the phosphorylated S1943 residue of a myosin-IIA heavy chain, and wherein absence of a phosphorylated S1943 residue of a myosin-IIA heavy chain does not indicate that cells of the tumor are likely to invade another organ or tissue.
A method for determining if a cancer is likely to metastasize comprising determining if a sample of the cancer, or a sample derived from the cancer, comprises a phosphorylated S1943 residue of a myosin-IIA heavy chain, wherein the cancer is likely to metastasize if the sample comprises the phosphorylated S1943 residue of a myosin-IIA heavy chain.
A method for determining if a cancer is likely to metastasize comprising determining if the cancer comprises a phosphorylated S1943 residue of a myosin-IIA heavy chain, wherein the cancer is likely to metastasize if the sample comprises the phosphorylated S1943 residue of a myosin-IIA heavy chain.
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Dependencies are inferred from the claim text.